Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Bioelectrochemistry. 2009 Nov;77(1):53-9. doi: 10.1016/j.bioelechem.2009.06.017. Epub 2009 Aug 13.
In this study a PVC membrane electrode for determination of ketotifen fumarate is reported, where ketotifen tetraphenylborate (Keto-TPB) was used as ion exchanger. The electrode has linear range of 5.6x10(-6)-1.0x10(-2) and 1.0x10(-5)-1.0x10(-2) mol/L, with detection limits 2.37x10(-6)and 4.60x10(-6) mol/L in batch and flow injection analysis (FIA), respectively. The electrodes show a Nernstian slope value (58.40 and 61.50 mV/decade in batch and FIA, respectively), and the response time is very short (<or=10 s). The potential is nearly stable over the pH range 2.0-8.0. Selectivity coefficient values towards different inorganic cations, sugars and amino acids reflect high selectivity of the prepared electrodes. These are used for determination of Ketotifen using potentiometric titration and standard addition methods in pure samples and its pharmaceutical preparations (Zaditen tablets and syrup). The average recovery values are 99.5 and 99.2% with RSD 1.4 and 1.2% for potentiometric titrations and standard addition methods, respectively. The electrode response at different temperatures was also studied.
在这项研究中，报道了一种用于测定富马酸酮替芬的 PVC 膜电极，其中酮替芬四苯硼酸盐（Keto-TPB）被用作离子交换剂。该电极在批处理和流动注射分析（FIA）中具有 5.6x10(-6)-1.0x10(-2) 和 1.0x10(-5)-1.0x10(-2) mol/L 的线性范围，检测限分别为 2.37x10(-6)和 4.60x10(-6) mol/L。电极呈现出 Nernstian 斜率值（在批处理和 FIA 中分别为 58.40 和 61.50 mV/decade），响应时间非常短（<或=10 s）。在 pH 值范围 2.0-8.0 内，电位几乎稳定。对不同无机阳离子、糖和氨基酸的选择性系数值反映了制备电极的高选择性。这些电极用于通过电位滴定法和标准加入法在纯样品及其药物制剂（Zaditen 片剂和糖浆）中测定酮替芬。对于电位滴定法和标准加入法，平均回收率分别为 99.5%和 99.2%，RSD 分别为 1.4%和 1.2%。还研究了电极在不同温度下的响应。
