用于无创血糖监测的光学相干断层扫描的体外研究。

In vitro studies toward noninvasive glucose monitoring with optical coherence tomography.

作者信息

Kinnunen Matti, Myllylä Risto, Jokela Tiina, Vainio Seppo

机构信息

Optoelectronics and Measurement Techniques Laboratory and Infotech Oulu, University of Finland.

出版信息

Appl Opt. 2006 Apr 1;45(10):2251-60. doi: 10.1364/ao.45.002251.

DOI:10.1364/ao.45.002251

PMID:16607992

Abstract

We use optical coherence tomography (OCT) to measure glucose-induced changes in Intralipid and in mouse skin samples in vitro. Mouse skin samples are cultured in a CO2 incubator before measurements are made with different amounts of added glucose concentrations. The results show that the glucose-induced changes in the OCT slope value vary between 20% and 52%/30 mM glucose in different mouse skin samples. This change is much larger than the change in 2% Intralipid (2.1%/30 mM) and in 5% Intralipid (0.86%/30 mM). Hence the results show that OCT has potential to monitor glucose-induced changes in tissues in vitro.

摘要

我们使用光学相干断层扫描（OCT）在体外测量葡萄糖诱导的脂质乳剂和小鼠皮肤样本中的变化。在用不同添加葡萄糖浓度进行测量之前，将小鼠皮肤样本置于二氧化碳培养箱中培养。结果显示，在不同小鼠皮肤样本中，葡萄糖诱导的OCT斜率值变化在20%至52%/30 mM葡萄糖之间。这种变化远大于2%脂质乳剂（2.1%/30 mM）和5%脂质乳剂（0.86%/30 mM）中的变化。因此，结果表明OCT有潜力在体外监测葡萄糖诱导的组织变化。