State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China.
Sunrise Technology Co., Ltd., Tianjin 300192, China.
Sensors (Basel). 2024 Sep 10;24(18):5879. doi: 10.3390/s24185879.
In non-invasive blood glucose measurement, the sensitivity of glucose-induced optical signals within human tissue is a crucial reference point. This study evaluates the sensitivity of glucose-induced diffuse reflectance in the 1000-1700 nm range. A key factor in understanding this sensitivity is the rate at which the scattering coefficient changes due to glucose, as it is significantly higher than in non-living media and predominantly influences the diffuse light signal level when blood glucose levels change. The study measured and calculated the changes in the scattering coefficient at 1314 nm, a wavelength chosen for its minimal interference from glucose absorption and other bodily constituents. Based on the Mie scattering theory and the results at 1314 nm, the changes in the scattering coefficient within the 1000-1700 nm range were estimated. Subsequently, the sensitivity of the glucose signal across this range was determined through Monte Carlo (MC) simulations. The findings from 25 human trials indicate that the measured sensitivities at five other typical wavelengths within this band generally align with the sensitivities calculated using the aforementioned method. This research can guide the identification of blood glucose signals and the selection of wavelengths for non-invasive blood glucose measurements.
在无创血糖测量中，人体组织内葡萄糖诱导的光信号灵敏度是一个关键参考指标。本研究评估了 1000-1700nm 范围内葡萄糖诱导的漫反射的灵敏度。理解这种灵敏度的一个关键因素是由于葡萄糖散射系数变化的速率，因为它明显高于非生命介质，并且当血糖水平变化时主要影响漫射光信号水平。该研究测量并计算了在 1314nm 处的散射系数变化，选择该波长是因为其最小受到葡萄糖吸收和其他身体成分的干扰。基于 Mie 散射理论和在 1314nm 处的结果，估算了 1000-1700nm 范围内散射系数的变化。随后，通过蒙特卡罗（MC）模拟确定了该范围内葡萄糖信号的灵敏度。25 项人体试验的结果表明，在该波段内另外五个典型波长处测量的灵敏度通常与使用上述方法计算的灵敏度一致。这项研究可以指导血糖信号的识别和无创血糖测量中波长的选择。
