胰腺黏液性囊性肿瘤恶性特征的临床病理及免疫组化分析
Clinicopathological and immunohistochemical analysis of malignant features in mucinous cystic tumors of the pancreas.
作者信息
Sawai Hirozumi, Okada Yiuji, Funahashi Hitoshi, Matsuo Yoichi, Hayakawa Tetsushi, Tanaka Moritsugu, Takeyama Hiromitsu, Manabe Tadao
机构信息
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan.
出版信息
Hepatogastroenterology. 2006 Mar-Apr;53(68):286-90.
BACKGROUND/AIMS: To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined clinicopathological features and immunohistochemical findings of MCT.
METHODOLOGY
We analyzed the expression of p53 protein, proliferating cell nuclear antigen, alpha6-integrin subunit, alpha5beta1-integrin, and interleukin-1 receptor type I in tumor specimens from eight patients with MCT.
RESULTS
The tumors were classified as mucinous cyst adenoma (n=6) or mucinous cyst adenocarcinoma (n=2). The actuarial five-year survival rate was 83.3%. All in eight MCTs had 'ovarian-type' stroma in the cyst wall. The alpha6-integrin subunit and p53 protein were expressed in adenocarcinoma tissues of MCTs, and in two adenomas the alpha6-integrin subunit and p53 protein were also co-expressed.
CONCLUSIONS
Our present results indicate that coexpression of the alpha6-integrin subunit and p53 protein should be appreciated as an indicator of malignancy in MCTs.
背景/目的：为了研究胰腺黏液性囊性肿瘤（MCTs）的恶性程度，我们检查了MCTs的临床病理特征和免疫组化结果。
方法
我们分析了8例MCT患者肿瘤标本中p53蛋白、增殖细胞核抗原、α6整合素亚基、α5β1整合素和I型白细胞介素受体的表达。
结果
肿瘤分为黏液性囊腺瘤（n = 6）或黏液性囊腺癌（n = 2）。实际五年生存率为83.3%。所有8例MCTs的囊壁均有“卵巢型”间质。α6整合素亚基和p53蛋白在MCTs的腺癌组织中表达，在2例腺瘤中α6整合素亚基和p53蛋白也共同表达。
结论
我们目前的结果表明，α6整合素亚基和p53蛋白的共同表达应被视为MCTs恶性程度的一个指标。
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