Paterson John R, Srivastava Rajeev, Baxter Gwen J, Graham Alan B, Lawrence James R
Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP, Scotland, UK.
J Agric Food Chem. 2006 Apr 19;54(8):2891-6. doi: 10.1021/jf058158w.
This work was done to determine the salicylate content of a variety of commonly used spices and to assess whether this potential dietary source of salicylate was bioavailable. Spices, Indian cooked dishes, and blood and urine samples taken after ingestion of a test meal were investigated for their salicylate content using high-performance liquid chromatography with electrochemical detection. The serum salicylic acid concentrations in samples from villagers in southern India were also measured and have been compared with typical European values. Salicylic acid was determined in all spices (up to 1.5 wt %) and cooked dishes. The salicylate content of blood and urine was shown to increase following consumption of the meal, indicating that this dietary source of salicylic acid was bioavailable. Salicylic acid levels in the serum from rural Indians were significantly (median almost 3-fold) higher than values previously measured in Western vegetarians. Chemoprotective aspirin is rapidly hydrolyzed to salicylic acid, and this phytochemical may contribute to the low cancer incidence in rural India.
开展这项工作是为了测定多种常用香料中的水杨酸盐含量，并评估水杨酸盐这一潜在的膳食来源是否具有生物利用性。使用高效液相色谱电化学检测法，对香料、印度烹饪菜肴以及摄入试验餐后采集的血液和尿液样本的水杨酸盐含量进行了研究。还测定了印度南部村民样本中的血清水杨酸浓度，并与欧洲的典型值进行了比较。在所有香料（含量高达1.5 wt%）和烹饪菜肴中均检测到了水杨酸。食用餐后，血液和尿液中的水杨酸盐含量有所增加，这表明这种膳食来源的水杨酸具有生物利用性。印度农村居民血清中的水杨酸水平显著高于此前在西方素食者中测得的值（中位数几乎高出3倍）。具有化学保护作用的阿司匹林会迅速水解为水杨酸，这种植物化学物质可能是印度农村地区癌症发病率较低的原因之一。
