Ehrs Per-Olof, Nokela Mika, Ställberg Björn, Hjemdahl Paul, Wikström Jonsson Eva
Clinical Pharmacology Unit L7:05, Karolinska University Hospital (Solna), SE-171 76 Stockholm, Sweden.
Chest. 2006 Apr;129(4):925-32. doi: 10.1378/chest.129.4.925.
STUDY OBJECTIVES AND DESIGN: Health-related quality of life (QoL) instruments are generally used for studies of asthma in specialized settings. For primary care use, there is a need for brief and simple questionnaires for structured patient-reported outcomes. We validated the Mini-Asthma Quality of Life Questionnaire (Mini-AQLQ), using the Asthma Quality of Life Questionnaire with standardized activities (AQLQ[S]) as the "gold standard." The Asthma Control Questionnaire (ACQ) was validated against the symptoms domain of the AQLQ(S). Patients were characterized by the Short Form-36 Health Survey (SF-36).
One hundred eight patients (68 women) with asthma diagnosed by their physicians from 24 primary care centers completed two visits (2 to 3 months apart). Their mean SF-36 scores were lower than the national norm for all domains.
The Mini-AQLQ and ACQ correlated well with the AQLQ(S). Reliability, determined in 57 patients with stable AQLQ(S) scores, was good. Both brief questionnaires detected improvement or deterioration of patients at the group level. Global ratings of disease severity by patients or clinicians correlated poorly with disease-specific QoL scores.
The Mini-AQLQ and ACQ instruments are sufficiently simple and robust to be suitable for research and quality of care monitoring in primary care at the group level. They may, after further validation, even be useful in the management of individual patients.
研究目的与设计：与健康相关的生活质量（QoL）工具通常用于在专业环境中对哮喘的研究。对于初级保健用途，需要简短且简单的问卷来获取结构化的患者报告结果。我们以标准化活动的哮喘生活质量问卷（AQLQ[S]）作为“金标准”，对迷你哮喘生活质量问卷（Mini - AQLQ）进行了验证。哮喘控制问卷（ACQ）对照AQLQ(S)的症状领域进行了验证。患者通过简短健康调查问卷36（SF - 36）进行特征描述。
来自24个初级保健中心的108名经医生诊断患有哮喘的患者（68名女性）完成了两次就诊（间隔2至3个月）。他们在所有领域的平均SF - 36得分均低于全国标准。
Mini - AQLQ和ACQ与AQLQ(S)相关性良好。在57名AQLQ(S)得分稳定的患者中确定的可靠性良好。这两种简短问卷在组水平上均检测到了患者的改善或恶化情况。患者或临床医生对疾病严重程度的总体评分与疾病特异性QoL得分相关性较差。
Mini - AQLQ和ACQ工具足够简单且可靠，适用于初级保健中组水平的研究和医疗质量监测。经过进一步验证后，它们甚至可能对个体患者的管理有用。
