Ozgen Alpaydin Aylin, Yorgancioğlu Arzu, Yilmaz Ozge, Bora Mine, Göktalay Tuğba, Celik Pinar, Yüksel Hasan
Department of Chest Diseases, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Tuberk Toraks. 2011;59(4):321-7.
We aimed to investigate the validity and reliability and of "Asthma Quality of Life Questionnaire (AQLQ)" in Turkish adult asthmatic patients. New or previously diagnosed [according to Global Initiative for Asthma (GINA) 2008] symptomatic 118 consecutive stable asthmatic patients between 18 and 55 years old were included. Asthma severity was determined and Turkish adaptation of the AQLQ was administered. Lara asthma symptom scales (LASS), pulmonary function tests, Turkish adaptation of Medical Outcomes Survey Short Form-36 (SF-36) were evaluated. All assessments were done twice at recruitment and after 10 weeks. During this period patients were allowed to make modifications on their medication when necessary. Among the recruited 118 patients 95 were female and 14 were lost in the follow-up. Sixty-two percentages of the patients had mild and 38% moderate asthma. The internal consistency of AQLQ was high (Cronbach's alpha 0.81-0.87) and item-total score correlations were ranging from 0.75-0.89. The cross-sectional and longitudinal correlations between AQLQ total and domain scores and SF36 domain scores were in a range of little or fair degree (r= 0.241-0.626, p< 0.005). Total AQLQ scores were observed significantly different according to disease severity and LASS both in the first (p< 0.001, both) and 10 weeks follow-up visits (p= 0.006, p< 0.001 respectively). A statistical significant change was observed in AQLQ symptom score as in total LASS changed (p< 0.001, both) in the follow-up. Our results demonstrated that Turkish version of AQLQ is feasible, reliable, valid and sensitive to changes in adult asthmatics.
我们旨在调查“哮喘生活质量问卷（AQLQ）”在土耳其成年哮喘患者中的有效性和可靠性。纳入了118例年龄在18至55岁之间、新诊断或先前已诊断（根据2008年全球哮喘防治创议[GINA]）的有症状的连续稳定哮喘患者。确定哮喘严重程度并进行AQLQ的土耳其语改编版测试。评估了劳拉哮喘症状量表（LASS）、肺功能测试、医学结局调查简表-36（SF-36）的土耳其语改编版。所有评估在招募时和10周后各进行两次。在此期间，允许患者在必要时调整用药。在招募的118例患者中，95例为女性，14例失访。62%的患者患有轻度哮喘，38%患有中度哮喘。AQLQ的内部一致性较高（Cronbach's α为0.81 - 0.87），项目总分相关性在0.75 - 0.89之间。AQLQ总分及各领域得分与SF36各领域得分之间的横断面和纵向相关性为低或中等程度（r = 0.241 - 0.626，p < 0.005）。在首次（p < 0.001，两者）和10周随访时，根据疾病严重程度和LASS观察到AQLQ总分有显著差异（分别为p = 0.006，p < 0.001）。随访中，AQLQ症状得分有统计学显著变化，与总LASS变化情况相同（p < 0.001，两者）。我们的结果表明，AQLQ土耳其语版对于成年哮喘患者是可行、可靠、有效的，且对变化敏感。
