Stefanidakis Michael, Koivunen Erkki
Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Blood. 2006 Sep 1;108(5):1441-50. doi: 10.1182/blood-2006-02-005363. Epub 2006 Apr 11.
Leukocyte motility is known to be dependent on both beta2-integrins and matrix metalloproteinases MMP-2/-9 or gelatinases, which mediate leukocyte adhesion and the proteolysis needed for invasion, respectively. Gelatinases not only play an important role in cell migration, tissue remodeling, and angiogenesis during development, but are also involved in the progression and invasiveness of many cancers, including leukemias. The concept that MMPs associate with integrins, as well as their importance in some physiologic and pathologic conditions, has been advanced previously but has not been examined on leukocytes. This review will examine mainly the function of the MMP-integrin complexes in normal leukocyte migration and the effect of integrin and broad-spectrum MMP inhibitors in tumor progression.
已知白细胞运动依赖于β2整合素和基质金属蛋白酶MMP-2/-9（即明胶酶），它们分别介导白细胞黏附以及侵袭所需的蛋白水解过程。明胶酶不仅在发育过程中的细胞迁移、组织重塑和血管生成中发挥重要作用，还参与包括白血病在内的许多癌症的进展和侵袭。基质金属蛋白酶与整合素相关的概念以及它们在某些生理和病理条件下的重要性此前已被提出，但尚未在白细胞上进行研究。本综述将主要探讨MMP-整合素复合物在正常白细胞迁移中的功能以及整合素和广谱MMP抑制剂对肿瘤进展的影响。
