Lundgren Jennifer D, Allison Kelly C, Stunkard Albert J
University of Pennsylvania School of Medicine Weight and Eating Disorder Program, Philadelphia, Pennsylvania 19104-3309, USA.
Int J Eat Disord. 2006 Sep;39(6):516-8. doi: 10.1002/eat.20269.
This study examined the extent to which the night eating syndrome (NES) affects first-degree relatives of NES and control probands.
NES participants and controls were assessed with the Night Eating Questionnaire (NEQ), the Night Eating Syndrome History and Inventory (NESHI), 10 day sleep and food records, the Eating Disorder Examination (EDE), the Structured Clinical Interview for DSM IV Axis I Disorders (SCID I), and a Family History Questionnaire (FHQ) to assess the presence of NES among first-degree relatives. A proband predictive model, using logistic regression analyses and the generalized estimating equation to control for correlation among observations within families was used to assess familial aggregation.
The odds of an NES proband having an affected first-degree relative were significantly greater than that of a control proband (odds ratio=4.9, p<.001). A number of covariates were included in the model: proband body mass index (BMI) (kg/m2), proband gender, proband age, proband ethnicity, first-degree relative gender, relationship to proband (i.e., mother, father, or sibling), and the interaction between relationship to proband and proband status (night eater or control); none was statistically significant (p>.05).
The study showed a strong aggregation of NES in families.
本研究调查了夜食综合征（NES）对NES先证者和对照先证者的一级亲属的影响程度。
使用夜食问卷（NEQ）、夜食综合征病史与量表（NESHI）、10天的睡眠和饮食记录、饮食失调检查（EDE）、DSM-IV轴I障碍结构化临床访谈（SCID I）以及家族史问卷（FHQ）对NES参与者和对照者进行评估，以评估一级亲属中NES的存在情况。采用先证者预测模型，通过逻辑回归分析和广义估计方程来控制家庭内观察值之间的相关性，以评估家族聚集性。
NES先证者有受影响的一级亲属的几率显著高于对照先证者（优势比=4.9，p<.001）。模型中纳入了多个协变量：先证者体重指数（BMI）（kg/m2）、先证者性别、先证者年龄、先证者种族、一级亲属性别、与先证者的关系（即母亲、父亲或兄弟姐妹）以及与先证者的关系和先证者状态（夜食者或对照）之间的相互作用；均无统计学意义（p>.05）。
该研究表明NES在家族中具有很强的聚集性。
