Nagy Ferenc, Molnár Tamás, Makula Eva, Kiss Ildikó, Milassin Péter, Zöllei Eva, Tiszlavicz László, Lonovics János
Szegedi Tudományegyetem, Szent-Györgyi Albert Orvos- és Gyógyszerésztudományi Centrum, Altalános Orvostudományi Kar, Szeged I. Belgyógyászati Klinika.
Orv Hetil. 2006 Feb 12;147(6):259-62.
Azathioprine-associated interstitial pneumonitis. The early hypersensitivity reaction and the late bone marrow depression are well known side effects of the azathioprine; the interstitial pneumonia is a rare complication. A 40-year old male patient was treated with azathioprine due to extensive ulcerative colitis for ten years. He complained seven days of fever, cough and catarrhal signs, without the symptoms of active colitis. The opportunistic infections were ruled out. Chest X-ray, CT and lung biopsy proved the presence of interstitial inflammation. The azathioprine therapy was discontinued as the potential source of the pulmonary infiltrate. As a result of steroid therapy, as well as emergency unit care, the pulmonary infiltrates decreased gradually. Three months later his ulcerative colitis relapsed, for this an ileo-anal pouch surgery was done. In case of atypical pneumonia, without proven opportunistic infection, azathioprine-associated interstitial pneumonitis may be present, which heal after cessation of the drug.
硫唑嘌呤相关的间质性肺炎。硫唑嘌呤早期的超敏反应和晚期的骨髓抑制是众所周知的副作用；间质性肺炎是一种罕见的并发症。一名40岁男性患者因广泛溃疡性结肠炎接受硫唑嘌呤治疗达十年。他主诉发热、咳嗽和卡他症状七天，无活动性结肠炎症状。排除了机会性感染。胸部X光、CT和肺活检证实存在间质性炎症。停用硫唑嘌呤治疗作为肺部浸润的潜在来源。经过类固醇治疗以及急诊室护理，肺部浸润逐渐减少。三个月后他的溃疡性结肠炎复发，为此进行了回肠肛管袋手术。对于非典型肺炎，在未证实有机会性感染的情况下，可能存在硫唑嘌呤相关的间质性肺炎，停药后可痊愈。
