[因英夫利昔单抗和硫唑嘌呤治疗导致的严重间质性肺病]

[Severe interstitial lung disease due to treatment with infliximab and azathioprine].

作者信息

Hansen Lars Koch, Cecere Stefano, Thøgersen Thøger

机构信息

Institut for Molekylær Medicin, Kardiovaskulær og Renal Forskning, Syddansk Universitet, Odense.

出版信息

Ugeskr Laeger. 2014 Dec 15;176(25A).

PMID:25497625

Abstract

A 41-year-old man developed severe interstitial lung disease (ILD) after treatment with infliximab (IFX) and azathioprine (AZA). A relapse of ulcerative colitis was treated with corticosteroids (CS) and IFX as rescue therapy. Following remission AZA was given as prophylaxis. AZA was initiated the same day as the third infusion of IFX (week 6). Within a few days he developed signs of lung involvement progressing into severe ILD. A high resolution computed tomography showed subacute hypersensitive pneumonitis. He was treated with oxygen and high dose CS. After three months his state of health had returned to normal.

摘要

一名41岁男性在接受英夫利昔单抗（IFX）和硫唑嘌呤（AZA）治疗后出现严重间质性肺病（ILD）。溃疡性结肠炎复发，采用皮质类固醇（CS）和IFX作为挽救疗法进行治疗。缓解后给予AZA作为预防用药。AZA在IFX第三次输注当天（第6周）开始使用。数天内，他出现肺部受累迹象，并进展为严重ILD。高分辨率计算机断层扫描显示为亚急性过敏性肺炎。他接受了吸氧和大剂量CS治疗。三个月后，他的健康状况恢复正常。