Ganong B R
Department of Biochemistry, University of Alabama, Birmingham 35294.
Am J Med Sci. 1991 Nov;302(5):304-12.
Cells of higher organisms respond to external stimuli with a cascade of intracellular biochemical events initiated by binding of a hormone, growth factor, or neurotransmitter to a specific cell surface receptor. Previously well-characterized signal transduction pathways involve cyclic nucleotides as intracellular second messengers. Over the past decade, increasing attention has been focused on other signaling pathways in which membrane lipids serve as second messengers or their precursors. This review describes current understanding of these pathways and points to recent discoveries likely to open new frontiers in the coming decade.
高等生物的细胞通过一系列细胞内生化事件来响应外部刺激，这些事件由激素、生长因子或神经递质与特定细胞表面受体结合引发。以前充分表征的信号转导途径涉及环核苷酸作为细胞内第二信使。在过去十年中，越来越多的注意力集中在其他信号转导途径上，其中膜脂作为第二信使或其前体。本综述描述了对这些途径的当前理解，并指出了可能在未来十年开辟新领域的近期发现。
