Hsu John T A, Wang Hsiang-Ching, Chen Guang-Wu, Shih Shin-Ru
Division of Biotechnology and Pharmaceutical Research, National Health Resarch Institutes, Zhunan, Taiwan.
Curr Pharm Des. 2006;12(11):1301-14. doi: 10.2174/138161206776361110.
Proteases fulfill multiple roles in health and disease, and considerable interest has been expressed in the design and development of synthetic inhibitors of disease-related proteases. Virus-encoded proteases have been shown to be involved in the replication of many viruses. The success of anti-HIV-1 therapy using specific and potent protease inhibitors suggests that viral proteases can be the valid molecular targets for the development of antiviral drugs against other viruses. Intensive genetic and biochemical studies have been conducted on viral proteases and new insights and results are rapidly emerging. This work reviews features of viral proteases with respective to the development of effective antiviral therapy.
蛋白酶在健康和疾病中发挥着多种作用，人们对与疾病相关蛋白酶的合成抑制剂的设计和开发表现出了浓厚兴趣。病毒编码的蛋白酶已被证明参与多种病毒的复制。使用特异性强效蛋白酶抑制剂进行抗HIV-1治疗的成功表明，病毒蛋白酶可以成为开发针对其他病毒的抗病毒药物的有效分子靶点。针对病毒蛋白酶已经开展了深入的遗传学和生物化学研究，新的见解和结果正在迅速涌现。本文综述了与有效抗病毒治疗发展相关的病毒蛋白酶的特征。
