小儿弥漫性脑桥肿瘤的纵向磁共振波谱成像以评估肿瘤侵袭性和进展情况。
Longitudinal MR spectroscopic imaging of pediatric diffuse pontine tumors to assess tumor aggression and progression.
作者信息
Thakur S B, Karimi S, Dunkel I J, Koutcher J A, Huang W
机构信息
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
出版信息
AJNR Am J Neuroradiol. 2006 Apr;27(4):806-9.
Abstract
Two pediatric patients with diffuse pontine tumors underwent MR spectroscopic imaging pre- and postradiation. Choline/creatine (Cho/Cr) and Cho/N-acetylaspartate (NAA) ratios were elevated before treatment, with no MR imaging contrast enhancement. These ratios were further elevated at 2 posttreatment follow-up studies, despite signs of excellent clinical improvement at initial follow-up. This study suggests that MR spectroscopic imaging is more specific in assessing the aggressiveness of diffuse pontine tumors than conventional MR imaging and can serve as a valuable tool in early prognostication.
摘要
两名患有弥漫性脑桥肿瘤的儿科患者在放疗前后接受了磁共振波谱成像。治疗前胆碱/肌酸（Cho/Cr）和胆碱/N-乙酰天门冬氨酸（NAA）比值升高，磁共振成像无对比增强。尽管在初始随访时有明显临床改善迹象，但在两次治疗后随访研究中这些比值进一步升高。本研究表明，磁共振波谱成像在评估弥漫性脑桥肿瘤的侵袭性方面比传统磁共振成像更具特异性，可作为早期预后评估的有价值工具。
相似文献
1
Longitudinal MR spectroscopic imaging of pediatric diffuse pontine tumors to assess tumor aggression and progression.小儿弥漫性脑桥肿瘤的纵向磁共振波谱成像以评估肿瘤侵袭性和进展情况。
AJNR Am J Neuroradiol. 2006 Apr;27(4):806-9.
2
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.接受放疗的小儿弥漫性脑干胶质瘤的纵向多体素磁共振波谱研究
Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):20-31. doi: 10.1016/j.ijrobp.2004.09.027.
3
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.弥漫性脑桥固有胶质瘤治疗期间纵向体积与代谢的差异演变：对当前疗效评估策略的启示
Neuroradiology. 2016 Oct;58(10):1027-1034. doi: 10.1007/s00234-016-1724-8. Epub 2016 Jul 20.
4
Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma.质子磁共振波谱预测弥漫性内在脑桥胶质瘤患儿的生存。
J Neurooncol. 2011 Nov;105(2):365-73. doi: 10.1007/s11060-011-0601-x. Epub 2011 May 13.
5
Magnetic resonance spectroscopy of atypical diffuse pontine masses.非典型桥脑弥漫性肿块的磁共振波谱分析
Neurosurg Focus. 2003 Jul 15;15(1):E5. doi: 10.3171/foc.2003.15.1.5.
6
7
MR spectroscopy using normalized and non-normalized metabolite ratios for differentiating recurrent brain tumor from radiation injury.利用归一化和非归一化代谢物比值的磁共振波谱分析鉴别脑肿瘤复发与放射性损伤。
Acad Radiol. 2011 Sep;18(9):1101-8. doi: 10.1016/j.acra.2011.05.006.
8
Developing a clinical decision model: MR spectroscopy to differentiate between recurrent tumor and radiation change in patients with new contrast-enhancing lesions.开发一种临床决策模型：磁共振波谱法鉴别新发强化病灶患者的肿瘤复发与放射性改变。
AJR Am J Roentgenol. 2009 Feb;192(2):W45-52. doi: 10.2214/AJR.07.3934.
9
A Novel Methodology for Applying Multivoxel MR Spectroscopy to Evaluate Convection-Enhanced Drug Delivery in Diffuse Intrinsic Pontine Gliomas.一种应用多体素磁共振波谱评估弥漫性脑桥内在型胶质瘤中对流增强药物递送的新方法。
AJNR Am J Neuroradiol. 2016 Jul;37(7):1367-73. doi: 10.3174/ajnr.A4713. Epub 2016 Mar 3.
10
White matter NAA/Cho and Cho/Cr ratios at MR spectroscopy are predictive of motor outcome in preterm infants.磁共振波谱分析显示，脑白质 NAA/Cho 和 Cho/Cr 比值可预测早产儿的运动预后。
Radiology. 2014 Apr;271(1):230-8. doi: 10.1148/radiol.13122679. Epub 2013 Nov 21.
引用本文的文献
1
Applications of artificial intelligence and advanced imaging in pediatric diffuse midline glioma.人工智能与先进成像技术在儿童弥漫性中线胶质瘤中的应用
Neuro Oncol. 2025 Jul 30;27(6):1419-1433. doi: 10.1093/neuonc/noaf058.
2
Magnetic Resonance Spectroscopy Metabolites as Biomarkers of Disease Status in Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG) Treated with Glioma-Associated Antigen Peptide Vaccines.磁共振波谱代谢物作为接受胶质瘤相关抗原肽疫苗治疗的小儿弥漫性脑桥内在型胶质瘤（DIPG）疾病状态的生物标志物
Cancers (Basel). 2022 Dec 5;14(23):5995. doi: 10.3390/cancers14235995.
3
2-D magnetic resonance spectroscopic imaging of the pediatric brain using compressed sensing.使用压缩感知技术进行儿科大脑的 2-D 磁共振波谱成像。
Pediatr Radiol. 2019 Dec;49(13):1798-1808. doi: 10.1007/s00247-019-04495-1. Epub 2019 Aug 28.
4
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.弥漫性脑桥固有胶质瘤治疗期间纵向体积与代谢的差异演变：对当前疗效评估策略的启示
Neuroradiology. 2016 Oct;58(10):1027-1034. doi: 10.1007/s00234-016-1724-8. Epub 2016 Jul 20.
5
Conventional and Advanced Imaging of Diffuse Intrinsic Pontine Glioma.弥漫性脑桥内在型胶质瘤的传统与先进成像技术
J Child Neurol. 2016 Oct;31(12):1386-93. doi: 10.1177/0883073816634855. Epub 2016 Apr 12.
6
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.儿童弥漫性内生性脑桥胶质瘤的单体素和多体素质子波谱分析。
Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):774-9. doi: 10.1016/j.ijrobp.2012.01.032. Epub 2012 Mar 23.
7
Elevated citrate in pediatric astrocytomas with malignant progression.恶性进展型小儿星形细胞瘤中柠檬酸水平升高。
Neuro Oncol. 2011 Oct;13(10):1107-17. doi: 10.1093/neuonc/nor087. Epub 2011 Jul 19.
8
Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma.质子磁共振波谱预测弥漫性内在脑桥胶质瘤患儿的生存。
J Neurooncol. 2011 Nov;105(2):365-73. doi: 10.1007/s11060-011-0601-x. Epub 2011 May 13.
9
Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications.磁共振波谱在儿科神经放射学中的临床与研究应用
Pediatr Radiol. 2010 Jan;40(1):3-30. doi: 10.1007/s00247-009-1450-z. Epub 2009 Nov 24.
10
Advanced imaging in paediatric neuroradiology.儿科神经放射学中的先进成像技术。
Pediatr Radiol. 2009 Jun;39 Suppl 3:456-63. doi: 10.1007/s00247-009-1230-9.
本文引用的文献
1
Magnetic resonance spectroscopy of atypical diffuse pontine masses.非典型桥脑弥漫性肿块的磁共振波谱分析
Neurosurg Focus. 2003 Jul 15;15(1):E5. doi: 10.3171/foc.2003.15.1.5.
2
Pontine glioblastoma multiforme initially presenting with leptomeningeal gliomatosis.最初表现为柔脑膜胶质瘤病的桥脑多形性胶质母细胞瘤
Neurol Med Chir (Tokyo). 2002 Jul;42(7):309-13. doi: 10.2176/nmc.42.309.
3
Magnetic resonance spectroscopy of the pediatric brain.小儿脑磁共振波谱分析
Top Magn Reson Imaging. 2001 Dec;12(6):435-52. doi: 10.1097/00002142-200112000-00005.
4
Clinical impact of MR spectroscopy when MR imaging is indeterminate for pediatric brain tumors.
AJR Am J Roentgenol. 1999 Jul;173(1):119-25. doi: 10.2214/ajr.173.1.10397111.
5
There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy.在新诊断的弥漫性脑干胶质瘤患儿的治疗中，超分割放疗没有作用：一项儿科肿瘤学组III期试验的结果，该试验比较了常规放疗与超分割放疗。
Int J Radiat Oncol Biol Phys. 1999 Mar 15;43(5):959-64. doi: 10.1016/s0360-3016(98)00501-x.
6
Proton magnetic resonance spectroscopy in pediatric neuroradiology.儿科神经放射学中的质子磁共振波谱分析
Pediatr Radiol. 1998 Nov;28(11):805-14. doi: 10.1007/s002470050470.
7
Proton MR spectroscopy of pediatric brain metabolic disorders.小儿脑代谢紊乱的质子磁共振波谱分析
Neuroimaging Clin N Am. 1998 Nov;8(4):781-807.
8
Proton MR spectroscopy of pediatric brain tumors.儿童脑肿瘤的质子磁共振波谱分析
Neuroimaging Clin N Am. 1998 Nov;8(4):753-79.
9
Pediatric brain stem gliomas: a review.小儿脑干胶质瘤：综述
Int J Radiat Oncol Biol Phys. 1998 Jan 15;40(2):265-71. doi: 10.1016/s0360-3016(97)00572-5.
Zotero 插件