Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Children's Hospital Dr., 45th St. and Penn Ave., Pittsburgh, PA 15201, USA.
Pediatr Radiol. 2010 Jan;40(1):3-30. doi: 10.1007/s00247-009-1450-z. Epub 2009 Nov 24.
Magnetic resonance spectroscopy (MRS) offers a unique, noninvasive approach to assess pediatric neurological abnormalities at microscopic levels by quantifying cellular metabolites. The most widely available MRS method, proton ((1)H; hydrogen) spectroscopy, is FDA approved for general use and can be ordered by clinicians for pediatric neuroimaging studies if indicated. There are a multitude of both acquisition and post-processing methods that can be used in the implementation of MR spectroscopy. MRS in pediatric neuroimaging is challenging to interpret because of dramatic normal developmental changes that occur in metabolites, particularly in the first year of life. Still, MRS has been proven to provide additional clinically relevant information for several pediatric neurological disease processes such as brain tumors, infectious processes, white matter disorders, and neonatal injury. MRS can also be used as a powerful quantitative research tool. In this article, specific research applications using MRS will be demonstrated in relation to neonatal brain injury and pediatric brain tumor imaging.
磁共振波谱（MRS）通过量化细胞代谢物，提供了一种独特的、非侵入性的方法，可在微观水平上评估儿科神经异常。最广泛应用的 MRS 方法是质子（(1)H；氢）波谱，已获得 FDA 批准用于常规使用，如果有指征，临床医生可以为儿科神经影像学研究开出处方。有许多采集和后处理方法可用于磁共振波谱的实施。由于代谢物，特别是在生命的第一年中，会发生明显的正常发育变化，因此儿科神经影像学中的 MRS 解读具有挑战性。尽管如此，MRS 已被证明可为几种儿科神经疾病过程（如脑肿瘤、感染过程、白质疾病和新生儿损伤）提供额外的临床相关信息。MRS 还可用作强大的定量研究工具。本文将展示 MRS 在新生儿脑损伤和小儿脑瘤成像方面的具体研究应用。
