Michielsen Helen J, Peros-Golubicic Tatjana, Drent Marjolein, De Vries Jolanda
Department Psychology and Health, Medical Psychology, Tilburg University, Tilburg, The Netherlands.
Respiration. 2007;74(4):401-5. doi: 10.1159/000092670. Epub 2006 Apr 7.
As sarcoidosis is a multisytemic disorder, patients may suffer from various symptoms. The relationship between frequently reported symptoms and quality of life (QOL) has not yet been studied.
The aim of the present cross-sectional study was to examine the predictive value of the most frequently reported subjective symptoms on QOL after controlling for demographic variables and clinical parameters.
A cross-sectional study was conducted at an outpatient pulmonary clinic in Zagreb, Croatia. One hundred and fifty outpatients with sarcoidosis were seen between January 2002 and May 2004. Symptoms were assessed with a symptom inventory questionnaire, and QOL was measured using the World Health Organization Quality of Life Assessment Instrument. Clinical parameters were derived from the patients' medical files. Regression analyses were performed to examine the predictive value of symptoms on QOL.
The four most frequently mentioned symptoms were fatigue, breathlessness, reduced exercise capacity and arthralgia. In various combinations, being female, using corticosteroids and fatigue predicted the QOL domains physical and psychological health as well as level of independence.
Fatigue appeared to be the most important symptom in predicting various QOL domains after controlling for demographics, disease stage and clinical parameters. Therefore, considering improvement in the patients' QOL, it is recommended to focus not only on objective health parameters, but also on fatigue in the management of sarcoidosis.
由于结节病是一种多系统疾病，患者可能会出现各种症状。常见症状与生活质量（QOL）之间的关系尚未得到研究。
本横断面研究的目的是在控制人口统计学变量和临床参数后，检验最常报告的主观症状对生活质量的预测价值。
在克罗地亚萨格勒布的一家门诊肺病诊所进行了一项横断面研究。2002年1月至2004年5月期间，共诊治了150例结节病门诊患者。使用症状清单问卷评估症状，并使用世界卫生组织生活质量评估工具测量生活质量。临床参数来自患者的病历。进行回归分析以检验症状对生活质量的预测价值。
最常提到的四种症状是疲劳、呼吸急促、运动能力下降和关节痛。女性、使用皮质类固醇和疲劳以各种组合预测了生活质量领域的身体健康、心理健康以及独立水平。
在控制人口统计学、疾病阶段和临床参数后，疲劳似乎是预测各种生活质量领域的最重要症状。因此，考虑到改善患者的生活质量，建议在结节病的管理中不仅要关注客观健康参数，还要关注疲劳。
