Michielsen Helen J, Drent Marjolein, Peros-Golubicic Tatjana, De Vries Jolanda
Department of Psychology and Health, Medical Psychology, Tilburg University, Room P507a, PO Box 90153, 5000 LE Tilburg, the Netherlands.
Chest. 2006 Oct;130(4):989-94. doi: 10.1378/chest.130.4.989.
Fatigue is one of the core symptoms of sarcoidosis patients. Although it is known that fatigue affects quality of life (QOL) in other patient groups, this relationship has never been studied in sarcoidosis patients using a reliable and valid fatigue scale and a multidimensional QOL instrument. The present cross-sectional study among sarcoidosis patients attempts to gain more insight into this relationship.
One hundred forty-five sarcoidosis patients of an outpatient pulmonary clinic in Zagreb, Croatia, completed the Fatigue Assessment Scale (FAS) and QOL scale (World Health Organization Quality of Life Assessment Instrument-100) between January 2002 and May 2004. Clinical parameters were derived from the patients' medical files.
Tired patients reported a worse QOL in all domains and fatigue negatively predicted all QOL domains by means of multivariate regression analyses (beta values ranging from - 0.31 to - 0.64, all p < 0.001). Corticosteroid use was not a predictor of QOL. Diffusion capacity of the lung for carbon monoxide was the only clinical parameter associated with a QOL domain, namely level of independence.
Fatigue was related to all QOL domains. Furthermore, standard clinical parameters were not associated with fatigue or QOL, except for level of independence. If these results were to be replicated in a prospective study, fatigue as measured by the FAS could be a good indicator of QOL in sarcoidosis patients.
疲劳是结节病患者的核心症状之一。尽管已知疲劳会影响其他患者群体的生活质量（QOL），但从未使用可靠有效的疲劳量表和多维生活质量工具对结节病患者的这种关系进行过研究。本项针对结节病患者的横断面研究旨在更深入地了解这种关系。
2002年1月至2004年5月期间，克罗地亚萨格勒布一家门诊肺部诊所的145名结节病患者完成了疲劳评估量表（FAS）和生活质量量表（世界卫生组织生活质量评估工具-100）。临床参数来自患者的病历。
疲劳患者在所有领域的生活质量均较差，通过多变量回归分析，疲劳对所有生活质量领域均产生负面预测作用（β值范围为-0.31至-0.64，所有p<0.001）。使用皮质类固醇并非生活质量的预测因素。肺一氧化碳弥散量是与生活质量领域（即独立水平）相关的唯一临床参数。
疲劳与所有生活质量领域相关。此外，除独立水平外，标准临床参数与疲劳或生活质量无关。如果这些结果能在前瞻性研究中得到重复验证，那么通过FAS测量的疲劳可能是结节病患者生活质量的良好指标。
