Kajita K, Yasuda K, Yamakita N, Murai T, Matsuda M, Morita H, Mori A, Murayama M, Tanahashi S, Sugiura M
Nagahama Red Cross Hospital, Shiga, Japan.
Endocrinol Jpn. 1991 Apr;38(2):121-9. doi: 10.1507/endocrj1954.38.121.
In an attempt to investigate the clinical significance of anti-pituitary antibodies in patients with hypopituitarism, anti-pituitary antibody in plasma was examined in 10 such patients (7 cases of isolated ACTH deficiency, 1 of partial hypopituitarism, and 2 of Sheehan's syndrome), on two or three occasions with an interval of more than 6 months (longitudinal study). In a total of 16 relatives of these 4 patients (2 cases of Sheehan's syndrome, one in each of partial hypopituitarism and isolated ACTH deficiency) and one patient not involved in the longitudinal study, anti-pituitary antibodies were also examined (family study). Anti-pituitary antibodies reacting with rat pituitary cytoplasmic antigens (pituitary cell antibodies: PCA) and pituitary cell surface antibodies (PCSA) reacting with GH3 cells and/or AtT-20 cells were measured with indirect immunofluorescence. The longitudinal study revealed the disappearance of antibodies in 3 patients, 2 PCA positive and one both PCA and PCSA positive. In 3 patients, altered antibody titers or a newly appearing antibody were found during the follow-up period. In 4 patients, the pituitary antibodies were negative during the follow-up periods. Of 16 family members studied, positive PCA was found in 3 members (2 in the families of patients with PCA positive Sheehan's syndrome, and 1 in the family of the patients with PCA positive partial hypopituitarism). Positive PCSA was found in 4 members (one in each of families of patients with partial hypopituitarism and isolated ACTH deficiency and of two cases of Sheehan's syndrome), and weakly positive PCSA was found in one family member of a patients with PCA positive Sheehan's syndrome.(ABSTRACT TRUNCATED AT 250 WORDS)
为了研究垂体功能减退患者中抗垂体抗体的临床意义，对10例此类患者（7例孤立性促肾上腺皮质激素缺乏、1例部分性垂体功能减退和2例席汉综合征）的血浆抗垂体抗体进行了两到三次检测，检测间隔超过6个月（纵向研究）。在这4例患者（2例席汉综合征、1例部分性垂体功能减退和1例孤立性促肾上腺皮质激素缺乏）的16名亲属以及1例未参与纵向研究的患者中，也检测了抗垂体抗体（家族研究）。采用间接免疫荧光法检测与大鼠垂体细胞质抗原反应的抗垂体抗体（垂体细胞抗体：PCA）以及与GH3细胞和/或AtT - 20细胞反应的垂体细胞表面抗体（PCSA）。纵向研究显示，3例患者抗体消失，其中2例PCA阳性，1例PCA和PCSA均阳性。3例患者在随访期间抗体滴度改变或出现新抗体。4例患者在随访期间垂体抗体为阴性。在研究的16名家庭成员中，3名成员PCA阳性（2名在PCA阳性的席汉综合征患者家族中，1名在PCA阳性的部分性垂体功能减退患者家族中）。4名成员PCSA阳性（分别在部分性垂体功能减退、孤立性促肾上腺皮质激素缺乏患者家族以及2例席汉综合征患者家族中各1名），在1例PCA阳性的席汉综合征患者的1名家庭成员中发现PCSA弱阳性。（摘要截选至250词）
