多层面错配修复系统。

The multifaceted mismatch-repair system.

作者信息

Jiricny Josef

机构信息

Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

出版信息

Nat Rev Mol Cell Biol. 2006 May;7(5):335-46. doi: 10.1038/nrm1907.

DOI:10.1038/nrm1907

PMID:16612326

Abstract

By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.

摘要

通过消除新合成DNA中的生物合成错误，错配修复（MMR）将DNA复制的保真度提高了几个数量级。MMR功能的丧失会导致突变体表型，从而使人易患癌症。但是MMR状态也会影响减数分裂和有丝分裂重组、DNA损伤信号传导、细胞凋亡以及细胞类型特异性过程，如类别转换重组、体细胞超突变和三核苷酸重复序列扩增。本文综述了我们目前对人类细胞中这个多方面DNA修复系统的理解。