Mehran R, Nikolsky E
Cardiovascular Research Foundation, New York, New York, USA.
Kidney Int Suppl. 2006 Apr(100):S11-5. doi: 10.1038/sj.ki.5000368.
Radiological procedures utilizing intravascular iodinated contrast media injections are being widely applied for both diagnostic and therapeutic purposes. This has resulted in an increasing incidence of procedure-related contrast-induced nephropathy (CIN). The definition of CIN includes absolute (> or = 0.5 mg/dl) or relative increase (> or = 25%) in serum creatinine at 48-72 h after exposure to a contrast agent compared to baseline serum creatinine values, when alternative explanations for renal impairment have been excluded. Although the risk of renal function impairment associated with radiological procedures is low (0.6-2.3%) in the general population, it may be very high in selected patient subsets (up to 20%), especially in patients with underlying cardiovascular disease. This review provides information on the known risk factors for the development of CIN, and completes with describing user-friendly CIN risk score based on the readily available information.
利用血管内注射碘化造影剂的放射学检查方法已广泛应用于诊断和治疗目的。这导致了与检查相关的造影剂肾病（CIN）发病率不断上升。CIN的定义包括在接触造影剂后48 - 72小时，血清肌酐较基线血清肌酐值出现绝对升高（≥0.5mg/dl）或相对升高（≥25%），且已排除肾功能损害的其他解释。虽然在普通人群中，与放射学检查相关的肾功能损害风险较低（0.6 - 2.3%），但在特定患者亚组中可能非常高（高达20%），尤其是患有潜在心血管疾病的患者。本综述提供了关于CIN发生的已知危险因素的信息，并基于易于获取的信息描述了便于使用的CIN风险评分。
