Husseinzadeh N, DeEulis T, Newman N, Wesseler T
Department of Obstetrics and Gynecology, University of Cincinnati, Ohio 45267-0526.
Gynecol Oncol. 1991 Dec;43(3):237-41. doi: 10.1016/0090-8258(91)90027-3.
Records of 28 patients with invasive squamous cell carcinoma of the vulva were analyzed with regard to age-specific incidence rate, associated human papillomavirus (HPV) changes, multifocal and unifocal distribution of the lesions, and incidence of nodal metastasis. The presence of HPV changes (koilocytosis and condyloma) around the neoplastic epithelium correlated with a mean age group younger than that of those without HPV changes (47 vs 77 years). All multifocal cancers were associated with HPV changes while only 35% of unifocal lesions were so associated. Patients with multifocal disease were found to have a mean age younger than that of those with unifocal disease (44 vs. 67). When patients with microinvasion were excluded, no patients with multifocal invasive cancer and HPV changes were found to have nodal metastases. In contrast, nodal metastases were present in 59% of patients with unifocal invasive cancer.
对28例浸润性外阴鳞状细胞癌患者的记录进行了分析，内容包括年龄特异性发病率、相关人乳头瘤病毒（HPV）变化、病变的多灶性和单灶性分布以及淋巴结转移发生率。肿瘤上皮周围HPV变化（挖空细胞和尖锐湿疣）的存在与平均年龄组相关，该年龄组比无HPV变化者的平均年龄组年轻（47岁对77岁）。所有多灶性癌症均与HPV变化相关，而只有35%的单灶性病变与HPV变化相关。发现多灶性疾病患者的平均年龄比单灶性疾病患者的平均年龄年轻（44岁对67岁）。当排除微浸润患者时，未发现有多灶性浸润癌且有HPV变化的患者发生淋巴结转移。相比之下，单灶性浸润癌患者中有59%发生了淋巴结转移。
