在手性硅胶存在下结合不对称自催化进行的自发绝对不对称合成。
Spontaneous absolute asymmetric synthesis in the presence of achiral silica gel in conjunction with asymmetric autocatalysis.
作者信息
Kawasaki Tsuneomi, Suzuki Kenta, Shimizu Masako, Ishikawa Keisuke, Soai Kenso
机构信息
Department of Applied Chemistry, Tokyo University of Science, Tokyo, Japan.
出版信息
Chirality. 2006 Aug;18(7):479-82. doi: 10.1002/chir.20273.
PMID:16612805
Abstract
An enantiomerically enriched pyrimidyl alkanol with either S or R configurations was obtained stochastically from the reaction between pyrimidine-5-carbaldehyde and diisopropylzinc in the presence of achiral silica gel in conjunction with asymmetric autocatalysis with amplification of chirality.
摘要
在手性硅胶存在下，嘧啶 - 5 - 甲醛与二异丙基锌反应，通过不对称自催化及手性放大，随机获得了具有S或R构型的对映体富集嘧啶基链烷醇。
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