Bryliakov Konstantin P
Novosibirsk State University, Pirogova 1, Novosibirsk 630090, Russia.
Boreskov Institute of Catalysis, Pr. Lavrentieva 5, Novosibirsk 630090, Russia.
Research (Wash D C). 2020 Aug 4;2020:5689246. doi: 10.34133/2020/5689246. eCollection 2020.
This surveys the recent experimental findings that suggest alternative chemical models of directed chirality amplification at the early, prebiotic Earth. It is believed that the chirality amplification step followed the initial emergence of small enantiomeric imbalance and preceded (as a necessary condition) the occurrence of homochiral biopolymers, assembled from enantiomerically pure building blocks. This work focuses on the chemical nature of possible mechanisms of primordial chirality enhancement, without going into detail of the preceding and subsequent phases of origination of biological homochirality and life on Earth. These mechanisms are discussed through the prism of integrity of biological natural selection and chemical kinetic selection.
本文综述了近期的实验结果，这些结果表明在早期的前生物地球存在手性定向放大的替代化学模型。据信，手性放大步骤是在小的对映体不平衡最初出现之后，并且在（作为必要条件）由对映体纯的构建块组装而成的同手性生物聚合物出现之前发生的。这项工作专注于原始手性增强可能机制的化学本质，而不深入探讨生物同手性和地球生命起源的先前和后续阶段的细节。通过生物自然选择和化学动力学选择的完整性这一视角来讨论这些机制。
