Mboto C I, Davies A, Fielder M, Jewell A P
Royal Victoria Hospital, Banjul, The Gambia.
Br J Biomed Sci. 2006;63(1):29-37. doi: 10.1080/09674845.2006.11732716.
Co-infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is becoming a major global problem, leading to increased morbidity and mortality in developed countries. Co-existence in sub-Saharan West Africa of a high prevalence of HIV and HCV, which share similar behavioural risk factors and modes of transmission, must be seen in the broader context of an emerging third epidemic of HIV and HCV co-infection, as many factors that may affect the spread of HIV and HCV co-infection are endemic in the continent, including host factors such as sexual behaviour, presence of other sexually transmitted diseases, female and male circumcision status, percutaneous and perinatal exposure, and poverty. This review examines the epidemiology, risk factors and transmission of HIV and HCV co-infection and draws attention to the possible emergence of an epidemic of HIV and HCV co-infection in the region.
人类免疫缺陷病毒（HIV）与丙型肝炎病毒（HCV）合并感染正成为一个重大的全球性问题，导致发达国家的发病率和死亡率上升。在撒哈拉以南的西非地区，HIV和HCV的高流行率并存，它们具有相似的行为危险因素和传播方式，这必须放在HIV和HCV合并感染这一正在出现的第三种流行病的更广泛背景下来看待，因为许多可能影响HIV和HCV合并感染传播的因素在该大陆是地方性的，包括性行为、其他性传播疾病的存在、女性和男性的包皮环切状况、经皮和围产期暴露以及贫困等宿主因素。本综述探讨了HIV和HCV合并感染的流行病学、危险因素及传播情况，并提请注意该地区可能出现的HIV和HCV合并感染流行。
