Chin H W, Bahrassa F S, Davis P, Ampil F L, Datta R, Perurena O
LSU Medical Center-Shreveport.
J La State Med Soc. 1991 Nov;143(11):33-6.
Prognosis of high-grade astrocytoma has been extremely disappointing and the median survival of patients with this tumor is less than 10 months at best. The most common cause of failure is local persistence of the tumor. Many neuro-oncologists have now turned to an alternative therapeutic approach involving brain brachytherapy (interstitial implantation) for the treatment of high-grade astrocytomas because in this manner a higher dose can be delivered to the tumor bed without excessively irradiating the surrounding normal brain tissue. Brachytherapy has shown some evidence of superior results in survival of malignant astrocytomas if properly performed by a qualified brachytherapy team. The objective of this report is to discuss the rationale and technique of brachytherapy in the management of high-grade astrocytoma as well as future prospects concerning this particular treatment modality.
高级别星形细胞瘤的预后一直非常令人失望，患有这种肿瘤的患者中位生存期最长不超过10个月。治疗失败的最常见原因是肿瘤局部残留。现在，许多神经肿瘤学家已转向一种替代治疗方法，即采用脑近距离放射治疗（间质植入）来治疗高级别星形细胞瘤，因为通过这种方式可以在不过度照射周围正常脑组织的情况下，向肿瘤床给予更高剂量的辐射。如果由合格的近距离放射治疗团队正确实施，近距离放射治疗已显示出在恶性星形细胞瘤生存方面有一些更好结果的证据。本报告的目的是讨论在高级别星形细胞瘤治疗中近距离放射治疗的基本原理和技术，以及这种特殊治疗方式的未来前景。
