Krishnan Chandra, Longacre Teri A
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hum Pathol. 2006 Mar;37(3):369-72. doi: 10.1016/j.humpath.2005.11.012.
Mammary carcinoma with multinucleated osteoclast-like giant cells (OGCs) is a rare, distinctive variant of breast carcinoma. To date, all of these instances have been described as part of an invasive carcinoma. Here, we report a case of ductal carcinoma in situ of the breast with numerous admixed OGCs present within gland lumens without an associated invasive component. Similar to invasive carcinomas with OGCs, both the in situ carcinoma and the OGCs exhibited overexpression for vascular endothelial growth factor. This case expands the spectrum of tumors associated with OGCs and provides further evidence for the possible role of vascular endothelial growth factor in the stromal-epithelial interactions of in situ mammary carcinoma.
伴有多核破骨细胞样巨细胞（OGCs）的乳腺癌是一种罕见的、独特的乳腺癌变体。迄今为止，所有这些病例均被描述为浸润性癌的一部分。在此，我们报告一例乳腺导管原位癌，其腺腔内存在大量混合的OGCs，且无相关浸润成分。与伴有OGCs的浸润性癌相似，原位癌和OGCs均表现出血管内皮生长因子的过表达。该病例拓宽了与OGCs相关的肿瘤谱，并为血管内皮生长因子在原位乳腺癌的基质-上皮相互作用中可能发挥的作用提供了进一步证据。
