Richter Georg, Uleer Christoph, Noesselt Thomas
Institute of Pathology, 31785, Hameln, Germany.
J Med Case Rep. 2011 Feb 27;5:85. doi: 10.1186/1752-1947-5-85.
To the best of our knowledge, this is the first case report of a multifocal (trifocal) invasive carcinoma of the breast containing osteoclast-like giant cells.
A 64-year-old Caucasian woman presented for routine mammography screening with three radiodense lesions in the lower inner quadrant of the right breast, a primary breast cancer. Microscopic examination showed three foci of invasive ductal carcinoma with multinucleated osteoclast-like giant cells. Osteoclast-like giant cells in breast cancer are a rare phenomenon. They are described in less than two percent of all breast cancers and occur in association with invasive ductal cancer and invasive lobular cancer. In addition, osteoclast-like giant cells have been described in several sarcomas and metaplastic carcinomas of the breast.
To the best of our knowledge, this is the first report of a multifocal infiltrating ductal carcinoma of the breast containing osteoclast-like giant cells. This could be an indication for a possible early event in carcinogenesis associated with a biological event or secretion that indicates the differentiation and/or migration of stromal cells or macrophages.
据我们所知，这是首例关于含有破骨细胞样巨细胞的多灶性（三灶性）乳腺浸润性癌的病例报告。
一名64岁的白人女性因常规乳房X线筛查就诊，其右乳内下象限有三个放射致密性病变，为原发性乳腺癌。显微镜检查显示三个伴有多核破骨细胞样巨细胞的浸润性导管癌灶。乳腺癌中的破骨细胞样巨细胞是一种罕见现象。在所有乳腺癌中，其发生率低于2%，且与浸润性导管癌和浸润性小叶癌相关。此外，在乳腺的几种肉瘤和化生癌中也有破骨细胞样巨细胞的描述。
据我们所知，这是首例关于含有破骨细胞样巨细胞的多灶性浸润性导管癌的报告。这可能表明在致癌过程中可能存在与生物学事件或分泌物相关的早期事件，该事件提示了基质细胞或巨噬细胞的分化和/或迁移。
