Swierczyńska-Machura Dominika, Krakowiak Anna, Wiszniewska Marta, Pałczyński Cezary
Z Ośrodka Alergii Zawodowej i Srodowiskowej i Kliniki Chorób Zawodowych Instytutu Medycyny Pracy im. prof. dra med. J. Nofera w Lodzi.
Med Pr. 2005;56(6):485-90.
Nitric oxide (NO) is an endogenous, soluble gas whose highly reactive molecules are involved in many biological and pathophysiological organic processes. It is generated from arginine through the action of the enzyme nitric oxide synthase (NOS). Over the recent years, accurate and non-invasive diagnostic methods have been searched for illustrating the allergic airway inflammation. Lately, great hopes have been associated with the use of measurements of exhaled nitric oxide (FENO) in the estimation of bronchial inflammation in asthmatic subjects. This method is non-invasive and can be frequently repeated. Furthermore, positive correlation between FENO and blood eosinophilia and induced sputum in atopic children and asthmatic adults has been observed. A significant increase in FENO after specific challenge test has also been shown. Therefore, determination of this parameter can be an additional source of information useful in the interpretation of occupational challenge tests in cases with boderline functional changes.
一氧化氮（NO）是一种内源性可溶性气体，其高反应性分子参与许多生物和病理生理有机过程。它由精氨酸通过一氧化氮合酶（NOS）的作用产生。近年来，一直在寻找准确且无创的诊断方法来阐明过敏性气道炎症。最近，呼气一氧化氮（FENO）测量在评估哮喘患者支气管炎症方面寄予了厚望。该方法无创且可频繁重复。此外，已观察到特应性儿童和哮喘成人中FENO与血液嗜酸性粒细胞增多和诱导痰之间呈正相关。特异性激发试验后FENO也有显著增加。因此，在具有临界功能变化的病例中，该参数的测定可以作为职业激发试验解读中有用的额外信息来源。
