Baraldi Eugenio, Carraro Silvia
Department of Pediatrics, University of Padua, Italy.
Paediatr Respir Rev. 2006;7 Suppl 1:S20-2. doi: 10.1016/j.prrv.2006.04.017. Epub 2006 Jun 5.
A growing interest has recently directed toward non invasive methods, such as exhaled nitric oxide (FE(NO)) measurement and exhaled breath condensate (EBC) collection, for the assessment of asthmatic inflammation. FE(NO) is a reliable marker of eosinophilic airway inflammation and it can be measured by means of a standardized technique in children starting from the age of 4. FE(NO) may have useful applications both in asthma diagnosis and monitoring. EBC is obtained cooling exhaled air and its composition is believed to mirror the characteristics of airway lining fluid. The compounds detected in EBC are markers of inflammation and oxidative stress occurring in asthmatic lung. While EBC is still only a research tool, FENO measurement is closer to clinical practice and lately it has been included in some treatment algorithms for asthma.
最近，人们越来越关注非侵入性方法，如呼出一氧化氮（FE(NO)）测量和呼出气冷凝物（EBC）采集，用于评估哮喘炎症。FE(NO)是嗜酸性气道炎症的可靠标志物，从4岁起就可以通过标准化技术在儿童中进行测量。FE(NO)在哮喘诊断和监测中可能都有有用的应用。EBC是通过冷却呼出的空气获得的，其成分被认为反映了气道内衬液的特征。在EBC中检测到的化合物是哮喘肺中发生的炎症和氧化应激的标志物。虽然EBC仍然只是一种研究工具，但FE(NO)测量更接近临床实践，最近它已被纳入一些哮喘治疗方案中。
