Herbert Alan, Gerry Norman P, McQueen Matthew B, Heid Iris M, Pfeufer Arne, Illig Thomas, Wichmann H-Erich, Meitinger Thomas, Hunter David, Hu Frank B, Colditz Graham, Hinney Anke, Hebebrand Johannes, Koberwitz Kerstin, Zhu Xiaofeng, Cooper Richard, Ardlie Kristin, Lyon Helen, Hirschhorn Joel N, Laird Nan M, Lenburg Marc E, Lange Christoph, Christman Michael F
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA.
Science. 2006 Apr 14;312(5771):279-83. doi: 10.1126/science.1124779.
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
肥胖是一种可遗传的特征，也是许多常见疾病的风险因素，如2型糖尿病、心脏病和高血压。我们对弗雷明汉心脏研究参与者的DNA样本进行了高密度全基因组扫描，以确定INSIG2基因附近与肥胖相关的常见基因变异。我们已在由西欧血统个体、非裔美国人及儿童组成的四个独立样本中重复了这一发现。这种易导致肥胖的基因型在10%的个体中存在。我们的研究表明，常见的基因多态性是肥胖的重要决定因素。
