Schwartz J, Elizan T S
J Neuropathol Exp Neurol. 1975 Jul;34(4):359-68. doi: 10.1097/00005072-197507000-00005.
Ultrastructural studies concerning the replication and release of a neuro-adapted strain of herpes simplex virus were carried out on acutely encephalitic mice. It was found that envelopment of nucleocapsid particles at the nuclear membrane of brain cells was inefficient, resulting in accumulation of unenveloped nucleocapsids in the cell cytoplasm. These nucleocapsids were associated with arrays of microtubules within cytoplasmic processes. Enveloped particles were rarely present in tissur spaces. Those that were seen appeared to be in a state of disintegration. This replication process of herpes simplex virus in the murine encephalitis model differs from that observed in tissue culture cells. The implications of these differences are discussed.
对急性脑炎小鼠进行了关于神经适应型单纯疱疹病毒复制和释放的超微结构研究。结果发现，在脑细胞的核膜处核衣壳颗粒的包膜形成效率低下，导致未包膜的核衣壳在细胞质中积累。这些核衣壳与细胞质突起内的微管阵列相关联。包膜颗粒很少出现在组织间隙中。所观察到的那些似乎处于解体状态。单纯疱疹病毒在鼠脑炎模型中的这种复制过程与在组织培养细胞中观察到的不同。讨论了这些差异的意义。
