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用疱疹病毒II型(HSVII)感染培养的中枢神经系统组织。重新评估。

Infection of cultivated CNS tissue with herpes virus, HSVII. A reappraisal.

作者信息

Fournier J G, Privat A, Bouteille M

出版信息

Acta Neuropathol. 1977 Aug 16;39(2):177-80. doi: 10.1007/BF00703326.

DOI:10.1007/BF00703326
PMID:197776
Abstract

Organized cultures of newborn rat and hamster cerebellum were infected with herpes virus type II, after 7 and 14 days "in vitro". 48 h after the infection, electron microscopic examination of the cultures showed that astrocytes contained numerous intranuclear and intracytoplasmic viral particles, while neurons remained apparently intact. The specificity of the infection for a given cell type is discussed.

摘要

新生大鼠和仓鼠小脑的组织培养物在“体外”培养7天和14天后,用II型疱疹病毒进行感染。感染后48小时,对培养物进行电子显微镜检查发现,星形胶质细胞含有大量核内和胞质内病毒颗粒,而神经元显然保持完整。文中讨论了针对特定细胞类型的感染特异性。

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本文引用的文献

1
THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING.疱疹病毒性脑炎的发病机制。I. 用荧光抗体染色法显示乳鼠神经系统的病毒传播途径。
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Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes.复溶鼠尾胶原蛋白用作在马克西莫夫载玻片和滚瓶中的盖玻片上进行组织培养的底物。
Lab Invest. 1958 Mar-Apr;7(2):134-7.
3
The outgrowth of rat cerebellum in organized culture.
大鼠小脑在组织培养中的生长。
Z Zellforsch Mikrosk Anat. 1973 Dec 31;146(1):45-67. doi: 10.1007/BF00306758.
4
Observations on uptake of herpes simplex virus in organized cultures of mammalian nervous tissue.对单纯疱疹病毒在哺乳动物神经组织有组织培养物中摄取情况的观察。
Acta Neuropathol. 1974 May 31;28(1):37-44. doi: 10.1007/BF00687516.
5
Ultrastructural aspects of herpes simplex virus infection in organized cultures of mammalian nervous tissue.哺乳动物神经组织有组织培养中单纯疱疹病毒感染的超微结构特征
Lab Invest. 1969 Jan;20(1):70-8.
6
Electron microscopic observations on the virus particles in Herpes simplex encephalitis.单纯疱疹性脑炎病毒颗粒的电子显微镜观察
J Clin Pathol. 1969 Jan;22(1):51-9. doi: 10.1136/jcp.22.1.51.
7
Electron microscopic observations on Herpesvirus hominis (herpes simplex virus) encephalitis in man.人单纯疱疹病毒脑炎的电子显微镜观察
Lab Invest. 1966 Dec;15(12):1966-81.
8
A study of the evolution of viral infection in experimental herpes simplex encephalitis and rabies by means of fluorescent antibody.利用荧光抗体对实验性单纯疱疹性脑炎和狂犬病病毒感染的演变进行的研究。
Acta Neuropathol. 1965 Nov 18;5(2):288-306. doi: 10.1007/BF00686524.
9
Experimental herpes simplex virus infection in the immature mouse brain.幼鼠大脑中的实验性单纯疱疹病毒感染
Acta Neuropathol. 1976 Aug 16;35(4):343-51.
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Herpes simplex virus encephalitis in suckling mice: ultrastructural studies of virus replication.乳鼠单纯疱疹病毒性脑炎:病毒复制的超微结构研究
J Neuropathol Exp Neurol. 1975 Jul;34(4):359-68. doi: 10.1097/00005072-197507000-00005.