Ciampor F, Szántó J
Acta Virol. 1982 Jan;26(1-2):67-72.
Ultrastructural changes showed the following characteristics of restricted replication of herpes simplex virus 1 (HSV 1) strains MA and HSZP in PK and XTC-2 cells: 1) minimal cytopathic changes in PK cells as compared to more pronounced alterations in XTC-2 cells; 2) formation of single nucleocapsids or their absence in the nuclei of PK cells infected with the HSZP strain; 3) lack of budding and envelopment and absence of reduplication of the nuclear membrane; 4) persistence of partially uncoated virions within the endocytic vacuoles in the cytoplasm of PK cells; and 5) formation of dense inclusion bodies in addition to the presence of defective virions in the cytoplasm of XTC-2 cells and vacuolation of their cytoplasmic membranes. The replication of HSV 1 in PK and XTC-2 cells seemed to be blocked at both early and late stages of virus replication. At low multiplicity of infection, no virus particles were formed.
超微结构变化显示单纯疱疹病毒1型（HSV 1）毒株MA和HSZP在PK和XTC - 2细胞中受限复制具有以下特征：1）与XTC - 2细胞中更明显的改变相比，PK细胞中的细胞病变变化最小；2）感染HSZP毒株的PK细胞核中形成单核衣壳或无单核衣壳；3）缺乏出芽和包膜，核膜无复制；4）PK细胞质内吞泡中存在部分未脱壳的病毒粒子；5）XTC - 2细胞质中除了存在缺陷病毒粒子外还形成致密包涵体，其细胞质膜空泡化。HSV 1在PK和XTC - 2细胞中的复制似乎在病毒复制的早期和晚期阶段均被阻断。在低感染复数时，未形成病毒颗粒。
