Popovych Oleksandr V, Hauptmann Christian, Tass Peter A
Institute of Medicine, Research Center Jülich, 52425, Jülich, Germany.
Biol Cybern. 2006 Jul;95(1):69-85. doi: 10.1007/s00422-006-0066-8. Epub 2006 Apr 14.
We present nonlinear delayed feedback stimulation as a technique for effective desynchronization. This method is intriguingly robust with respect to system and stimulation parameter variations. We demonstrate its broad applicability by applying it to different generic oscillator networks as well as to a population of bursting neurons. Nonlinear delayed feedback specifically counteracts abnormal interactions and, thus, restores the natural frequencies of the individual oscillatory units. Nevertheless, nonlinear delayed feedback enables to strongly detune the macroscopic frequency of the collective oscillation. We propose nonlinear delayed feedback stimulation for the therapy of neurological diseases characterized by abnormal synchrony.
我们提出将非线性延迟反馈刺激作为一种实现有效去同步化的技术。该方法在系统和刺激参数变化方面具有令人感兴趣的稳健性。我们通过将其应用于不同的通用振荡器网络以及一群爆发性神经元来证明其广泛的适用性。非线性延迟反馈特别能抵消异常相互作用，从而恢复各个振荡单元的固有频率。然而，非线性延迟反馈能够强烈改变集体振荡的宏观频率。我们提出将非线性延迟反馈刺激用于治疗以异常同步为特征的神经疾病。
