一名免疫缺陷患者出现与诱导性共刺激分子表达缺陷相关的克罗恩样结肠炎。 - Suppr

Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator.

作者信息

Mudter Jonas, Wirtz Stefan, Weigmann Benno, Tiede Imke, Tubbe Ingrid, Kiesslich Ralf, Galle Peter R, Lehr Hans A, Neurath Markus F

机构信息

First Medical Clinic, Johannes-Gutenberg-University, Mainz, Germany.

出版信息

Dig Dis Sci. 2006 Apr;51(4):711-7. doi: 10.1007/s10620-006-3196-x.

DOI:10.1007/s10620-006-3196-x

PMID:16614993

Abstract

摘要

相似文献

Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator.一名免疫缺陷患者出现与诱导性共刺激分子表达缺陷相关的克罗恩样结肠炎。

Dig Dis Sci. 2006 Apr;51(4):711-7. doi: 10.1007/s10620-006-3196-x.

Common variable immunodeficiency masquerading as Crohn's ileocolitis.

Inflamm Bowel Dis. 2006 Feb;12(2):151-2. doi: 10.1097/01.MIB.0000200344.61707.9c.

Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-α in inflammatory bowel disease.干扰素调节因子1和骨桥蛋白对炎症性肠病中TNF-α诱导的上皮细胞凋亡的相反作用。

Inflamm Bowel Dis. 2014 Nov;20(11):1950-61. doi: 10.1097/MIB.0000000000000192.

Is histology useful for the assessment of the efficacy of immunosuppressive agents in IBD and if so, how should it be applied ?组织学检查对评估免疫抑制剂治疗炎症性肠病的疗效是否有用？如果有用，应如何应用？

Acta Gastroenterol Belg. 2004 Jul-Sep;67(3):285-9.

[Colonic expression of gamma-interferon and interleukin-10 in Crohn's disease and ulcerative colitis].[γ-干扰素和白细胞介素-10在克罗恩病和溃疡性结肠炎中的结肠表达]

Presse Med. 2005 Jan 15;34(1):8-12. doi: 10.1016/s0755-4982(05)83876-x.

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.MicroRNA-31 可减少结肠上皮的炎症信号并促进其再生，微球递送模拟物可减少小鼠的结肠炎。

Gastroenterology. 2019 Jun;156(8):2281-2296.e6. doi: 10.1053/j.gastro.2019.02.023. Epub 2019 Feb 16.

Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis.克罗恩病而非溃疡性结肠炎的肠道黏膜病变中白细胞介素-2信使核糖核酸增加。

Gastroenterology. 1992 May;102(5):1620-7. doi: 10.1016/0016-5085(92)91722-g.

Microaggregate of immunostained macrophages in noninflamed gastroduodenal mucosa: a new useful histological marker for differentiating Crohn's colitis from ulcerative colitis.非炎症性胃十二指肠黏膜中免疫染色巨噬细胞的微聚集体：一种区分克罗恩病性结肠炎与溃疡性结肠炎的新的有用组织学标志物。

Am J Gastroenterol. 2000 Aug;95(8):1967-73. doi: 10.1111/j.1572-0241.2000.02258.x.

Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease.细胞因子/趋化因子转录谱反映了克罗恩病中的黏膜炎症。

Int J Colorectal Dis. 2004 Jul;19(4):308-15. doi: 10.1007/s00384-003-0554-4. Epub 2003 Nov 7.

What histologic features best differentiate Crohn's disease from ulcerative colitis?哪些组织学特征最能区分克罗恩病和溃疡性结肠炎？

Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S168-9. doi: 10.1002/ibd.20598.

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Primary Humoral Immune Deficiencies: Overlooked Mimickers of Chronic Immune-Mediated Gastrointestinal Diseases in Adults.原发性体液免疫缺陷：被忽视的成人慢性免疫介导的胃肠道疾病的模拟者。

Int J Mol Sci. 2020 Jul 23;21(15):5223. doi: 10.3390/ijms21155223.

Gastrointestinal Disorders Associated with Primary Immunodeficiency Diseases.原发性免疫缺陷病相关的胃肠道疾病。

Clin Rev Allergy Immunol. 2019 Oct;57(2):145-165. doi: 10.1007/s12016-018-8689-9.

本文引用的文献

Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.炎症性肠病中信号转导子和转录激活子（STAT）因子的激活模式

Am J Gastroenterol. 2005 Jan;100(1):64-72. doi: 10.1111/j.1572-0241.2005.40615.x.

Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity.共刺激信号缺陷的同种异体细胞激活人T细胞可诱导表达可诱导共刺激分子的无反应性T细胞，这些T细胞具有调节细胞活性。

J Immunol. 2004 May 1;172(9):5371-8. doi: 10.4049/jimmunol.172.9.5371.

Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.诱导性共刺激分子的过表达及其在炎症性肠病固有层T细胞中的作用。

Gastroenterology. 2004 Mar;126(3):829-39. doi: 10.1053/j.gastro.2003.12.011.

Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis.在缺乏CD28的情况下阻断诱导性共刺激分子会损害小鼠结肠炎中的Th1细胞和CD25 +调节性T细胞。

Int Immunol. 2004 Feb;16(2):205-13. doi: 10.1093/intimm/dxh019.

Lymphoproliferative disease in antibody deficiency: a multi-centre study.抗体缺陷中的淋巴增殖性疾病：一项多中心研究。

Clin Exp Immunol. 2003 Nov;134(2):314-20. doi: 10.1046/j.1365-2249.2003.02253.x.

Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections.ICOS-B7RP-1共刺激途径在调节对硕大利什曼原虫和巴西日圆线虫感染的免疫反应中的作用。

Immunol Lett. 2003 Oct 31;89(2-3):193-9. doi: 10.1016/s0165-2478(03)00137-8.

Association of common variable immunodeficiency with atypical collagenous colitis.普通可变免疫缺陷与非典型胶原性结肠炎的关联。

Eur J Gastroenterol Hepatol. 2003 Sep;15(9):1051-3. doi: 10.1097/00042737-200309000-00019.

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.ICOS纯合缺失与成人期常见可变免疫缺陷相关。

Nat Immunol. 2003 Mar;4(3):261-8. doi: 10.1038/ni902. Epub 2003 Feb 10.

ICOS costimulation in inflammatory bowel disease.炎症性肠病中的ICOS共刺激

J Gastroenterol. 2002 Nov;37 Suppl 14:78-81. doi: 10.1007/BF03326419.

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.T-bet是一种由STAT1诱导的、调节初始CD4+ T细胞中IL-12R表达的调节因子。

Nat Immunol. 2002 Jun;3(6):549-57. doi: 10.1038/ni794. Epub 2002 May 13.

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Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator.

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