Köksal Deniz, Unsal Ebru, Poyraz Bariş, Kaya Akin, Savaş Hacer, Sipit Tuğrul, Gönüllü Uğur
Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Department of Chest Diseases, Ankara, Turkey.
Tuberk Toraks. 2006;54(1):17-21.
Interferon (IFN)-gamma plays a pivotal role in protective immunity against Mycobacterium tuberculosis. Elevations of IFN-gamma have been found in the affected lung and bloodstream of patients with pulmonary tuberculosis. In the present study, we aimed to investigate the role of serum IFN-gamma level in the differential diagnosis of active and inactive pulmonary tuberculosis. Fourty seven patients with newly diagnosed active pulmonary tuberculosis, 21 patients with inactive pulmonary tuberculosis, and 20 healthy volunteers were enrolled in the study. Serum samples were collected from each subject and stored at - 70 degrees C until the analysis of IFN-gamma. The mean value of IFN-gamma levels were 9.3 +/- 4.6 pg/mL in patients with newly diagnosed pulmonary tuberculosis, 9.8 +/- 3.8 pg/mL in patients with inactive tuberculosis, and 10.2 +/- 3.4 pg/mL in healthy controls. The comparison of IFN-gamma levels of the three groups was not found statistically significant (p= 0.4). Serum IFN-gamma level was not found to be valuable in the differential diagnosis of active and inactive pulmonary tuberculosis.
干扰素-γ（IFN-γ）在抗结核分枝杆菌的保护性免疫中起关键作用。在肺结核患者的受累肺组织和血液中已发现IFN-γ水平升高。在本研究中，我们旨在探讨血清IFN-γ水平在活动性和非活动性肺结核鉴别诊断中的作用。本研究纳入了47例新诊断的活动性肺结核患者、21例非活动性肺结核患者和20名健康志愿者。从每个受试者采集血清样本，并在-70℃保存，直至分析IFN-γ。新诊断肺结核患者的IFN-γ水平平均值为9.3±4.6 pg/mL，非活动性肺结核患者为9.8±3.8 pg/mL，健康对照者为10.2±3.4 pg/mL。三组IFN-γ水平的比较未发现有统计学意义（p = 0.4）。血清IFN-γ水平在活动性和非活动性肺结核的鉴别诊断中无价值。
