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[新诊断的阵发性精神分裂症患者免疫的T淋巴细胞系统状态]

[Status of the T-lymphocyte system of immunity in patients with newly diagnosed paroxysmal schizophrenia].

作者信息

Rogozhnikova O A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(8):47-9.

PMID:1661515
Abstract

Overall 19 male patients with attack-like schizophrenia were examined within the first 1-2 months since the disease manifestation till the onset of the antipsychotic treatment. To characterize the T immunity system, use was made of the E-rosette formation test and a kit of monoclonal antibodies. It has been revealed, that in the peripheral blood of the schizophrenic patients, the T lymphocyte count was noticeably decreased, the relative count of the cells of both the regulatory populations was increased, being statistically significant only for helpers. The ratio of T helpers to T suppressors remained unchanged. The count of poorly differentiated T lymphocytes turned out noticeably increased.

摘要

在19例急性起病型精神分裂症男性患者中,于疾病显现后的最初1 - 2个月内,直至抗精神病治疗开始前进行了检查。为了表征T免疫系统,采用了E花环形成试验和一套单克隆抗体。结果显示,在精神分裂症患者的外周血中,T淋巴细胞计数显著降低,两个调节群体细胞的相对计数均增加,仅辅助性T细胞具有统计学意义。辅助性T细胞与抑制性T细胞的比例保持不变。低分化T淋巴细胞计数明显增加。

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