[持续性进行性青少年精神分裂症中的抑制性T淋巴细胞]
[Suppressor T-lymphocytes in continuously progressive juvenile schizophrenia].
作者信息
Maznina T P, Mikheeva T V, Lavrov V F, Abramova L I, Koliaskina G I
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(7):1065-9.
The study of T lymphocyte suppressors in juvenile continuously progressive schizophrenia showed that the number of suppressor cells in patients was significantly decreased as compared to a group of mentally normal donors; 20.4% and 28.9% respectively. The parallel study of the number of suppressor cells in the peripheral blood and the proliferative activity of T lymphocytes upon their stimulation with mitogenic lectins of PHA and Con A demonstrated that in the mentally normal donors, these parameters were inversely correlated, whereas in the patients with juvenile continuously progressive schizophrenia, there was no such correlation between the above indices. The data obtained are indicative of the impaired regulatory activity of T lymphocyte suppressors in this group of schizophrenic patients.
对青少年持续进行性精神分裂症患者的T淋巴细胞抑制因子研究表明，与一组精神正常的供体相比，患者体内抑制细胞数量显著减少，分别为20.4%和28.9%。对外周血中抑制细胞数量以及用PHA和Con A促有丝分裂凝集素刺激T淋巴细胞后的增殖活性进行的平行研究表明，在精神正常的供体中，这些参数呈负相关，而在青少年持续进行性精神分裂症患者中，上述指标之间不存在这种相关性。所获得的数据表明，这组精神分裂症患者中T淋巴细胞抑制因子的调节活性受损。
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