Pizon Anthony F, Brooks Daniel E
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA.
Clin Toxicol (Phila). 2006;44(2):181-3. doi: 10.1080/15563650500514582.
When given early, fomepizole has demonstrated an effective role in the treatment of ethylene glycol (EG) intoxication, often eliminating the need for hemodialysis (HD). Many indications for HD have been suggested for EG intoxication. We present a case of EG intoxication with the second highest reported EG concentration. Despite early treatment with fomepizole and without the development of acidosis or renal insufficiency, the patient required HD for hyperosmolality and subsequent electrolyte imbalances. Indications for HD following EG intoxication are discussed.
早期给予甲吡唑已证明在乙二醇（EG）中毒治疗中发挥有效作用，常常无需进行血液透析（HD）。对于EG中毒，已提出许多进行HD的指征。我们报告一例EG浓度为报告中第二高的EG中毒病例。尽管早期使用甲吡唑治疗且未发生酸中毒或肾功能不全，但该患者因高渗状态及随后的电解质失衡而需要进行HD。本文讨论了EG中毒后进行HD的指征。
