纳米电喷雾中的脉动模式以及施加电压对电流和流速的影响。

Pulsation modes and the effect of applied voltage on current and flow rate in nanoelectrospray.

作者信息

Alexander Matthew S, Paine Mark D, Stark John P W

机构信息

Department of Engineering, Queen Mary, University of London, London, UK.

出版信息

Anal Chem. 2006 Apr 15;78(8):2658-64. doi: 10.1021/ac0520036.

DOI:10.1021/ac0520036

PMID:16615777

Abstract

New modes of nanoelectrospray (nES) have been identified that exhibit stable high-frequency current oscillations in the kilohertz range. In-line flow rate measurements during nES have for the first time allowed the accurate determination of the spray current and volumetric flow rate dependence on applied voltage. High-speed video imaging has revealed that each current pulse corresponds to the periodic formation of a short-lived stable cone-jet structure at the capillary tip. These findings are of particular importance and suggest greater process monitoring and control in nES-MS systems is necessary if efficiency and ion yield are to be optimized.

摘要

已发现纳米电喷雾（nES）的新模式，其在千赫兹范围内呈现稳定的高频电流振荡。纳米电喷雾过程中的在线流速测量首次实现了对喷雾电流以及体积流速与施加电压之间依赖关系的精确测定。高速视频成像显示，每个电流脉冲都对应于在毛细管尖端周期性形成的一种短暂稳定的锥喷结构。这些发现尤为重要，表明如果要优化效率和离子产率，在纳米电喷雾-质谱（nES-MS）系统中进行更多的过程监测和控制是必要的。