Bushey Jared M, Kaplan Desmond A, Danell Ryan M, Glish Gary L
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-3290, USA.
Instrum Sci Technol. 2009;37(3):257-273. doi: 10.1080/10739140902831313.
The temporal response of pulsed nano-electrospray ionization mass spectrometry (nano-ESI-MS) was studied and its influence on ion formation and detection was characterized. Rise and decay times for the mass resolved ion current were determined to be 20 ± 3 msec and 61 ± 5 msec, respectively, which led to a maximum pulse rate of 12 Hz. Pulsed nano-ESI operation was demonstrated from a multi-sprayer source controlled by a high voltage pulsing circuit constructed in-house. The desired source mode of operation (e.g. pulsing or continuous) can be realized solely by controlling the voltage applied to each sprayer.
研究了脉冲纳米电喷雾电离质谱（nano-ESI-MS）的时间响应，并表征了其对离子形成和检测的影响。质量分辨离子电流的上升和衰减时间分别确定为20±3毫秒和61±5毫秒，这导致最大脉冲速率为12赫兹。通过由内部构建的高压脉冲电路控制的多喷头源展示了脉冲纳米电喷雾操作。仅通过控制施加到每个喷头的电压，就可以实现所需的源操作模式（例如脉冲或连续）。
