脉冲纳米电喷雾电离：时间响应特性及带扩口入口毛细管的实现
Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary.
作者信息
Bushey Jared M, Kaplan Desmond A, Danell Ryan M, Glish Gary L
机构信息
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-3290, USA.
出版信息
Instrum Sci Technol. 2009;37(3):257-273. doi: 10.1080/10739140902831313.
Abstract
The temporal response of pulsed nano-electrospray ionization mass spectrometry (nano-ESI-MS) was studied and its influence on ion formation and detection was characterized. Rise and decay times for the mass resolved ion current were determined to be 20 ± 3 msec and 61 ± 5 msec, respectively, which led to a maximum pulse rate of 12 Hz. Pulsed nano-ESI operation was demonstrated from a multi-sprayer source controlled by a high voltage pulsing circuit constructed in-house. The desired source mode of operation (e.g. pulsing or continuous) can be realized solely by controlling the voltage applied to each sprayer.
摘要
研究了脉冲纳米电喷雾电离质谱（nano-ESI-MS）的时间响应，并表征了其对离子形成和检测的影响。质量分辨离子电流的上升和衰减时间分别确定为20±3毫秒和61±5毫秒，这导致最大脉冲速率为12赫兹。通过由内部构建的高压脉冲电路控制的多喷头源展示了脉冲纳米电喷雾操作。仅通过控制施加到每个喷头的电压，就可以实现所需的源操作模式（例如脉冲或连续）。
相似文献
1
Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary.脉冲纳米电喷雾电离：时间响应特性及带扩口入口毛细管的实现
Instrum Sci Technol. 2009;37(3):257-273. doi: 10.1080/10739140902831313.
2
Electric modeling and characterization of pulsed high-voltage nanoelectrospray ionization sources by a miniature ion trap mass spectrometer.利用微型离子阱质谱仪对脉冲高压纳米电喷雾电离源进行电学建模与特性表征
J Mass Spectrom. 2019 Jul;54(7):583-591. doi: 10.1002/jms.4361.
3
Sheathless capillary electrophoresis-mass spectrometry using a pulsed electrospray ionization source.使用脉冲电喷雾电离源的无鞘毛细管电泳-质谱联用技术。
Electrophoresis. 2006 Jun;27(11):2083-90. doi: 10.1002/elps.200500811.
4
Incorporation of a flared inlet capillary tube on a fourier transform ion cyclotron resonance mass spectrometer.在傅里叶变换离子回旋共振质谱仪上采用扩口进样毛细管柱。
J Am Soc Mass Spectrom. 2006 Jun;17(6):772-779. doi: 10.1016/j.jasms.2006.02.011. Epub 2006 Apr 17.
5
Accurate mass measurement in nano-electrospray ionization mass spectrometry by alternate switching of high voltage between sample and reference sprayers.通过在样品喷雾器和参比喷雾器之间交替切换高压，在纳升电喷雾电离质谱中进行精确质量测量。
Rapid Commun Mass Spectrom. 2005;19(4):540-6. doi: 10.1002/rcm.1813.
6
Optimization and evaluation of a sheathless capillary electrophoresis-electrospray ionization mass spectrometry platform for peptide analysis: comparison to liquid chromatography-electrospray ionization mass spectrometry.鞘液免进毛细管电泳-电喷雾电离质谱平台用于肽分析的优化与评估：与液相色谱-电喷雾电离质谱的比较。
Anal Chem. 2011 Oct 1;83(19):7297-305. doi: 10.1021/ac2010372. Epub 2011 Sep 1.
7
Comparing and combining capillary electrophoresis electrospray ionization mass spectrometry and nano-liquid chromatography electrospray ionization mass spectrometry for the characterization of post-translationally modified histones.比较和结合毛细管电泳电喷雾电离质谱和纳流液相色谱电喷雾电离质谱用于翻译后修饰组蛋白的表征。
Mol Cell Proteomics. 2013 Sep;12(9):2640-56. doi: 10.1074/mcp.M112.024109. Epub 2013 May 29.
8
Simultaneous detection of polar and nonpolar compounds by ambient mass spectrometry with a dual electrospray and atmospheric pressure chemical ionization source.使用双电喷雾和大气压化学电离源的常压质谱法同时检测极性和非极性化合物。
Anal Chem. 2015 Feb 3;87(3):1743-8. doi: 10.1021/ac503625m. Epub 2015 Jan 20.
9
[Rapid detection of four amphetamine-type drugs in hair by pulsed direct current electrospray mass spectrometry].[脉冲直流电喷雾质谱法快速检测毛发中的四种苯丙胺类药物]
Se Pu. 2023 Dec;41(12):1141-1148. doi: 10.3724/SP.J.1123.2023.04002.
10
Pulsed electrospray for mass spectrometry.用于质谱分析的脉冲电喷雾
Anal Chem. 2001 Oct 1;73(19):4748-53. doi: 10.1021/ac0103118.
引用本文的文献
1
Critical Role of Voltage Application Points in "Analog" and "Digital" Electrospray Ionization Mass Spectrometry.电压施加点在“模拟”和“数字”电喷雾电离质谱中的关键作用
J Am Soc Mass Spectrom. 2025 May 7;36(5):1191-1199. doi: 10.1021/jasms.5c00082. Epub 2025 Apr 15.
2
Electric Field-Modulated Electrospray Ionization Mass Spectrometry for Quantity Calibration and Mass Tracking.用于定量校准和质量追踪的电场调制电喷雾电离质谱法
J Am Soc Mass Spectrom. 2024 Sep 4;35(9):2064-2072. doi: 10.1021/jasms.4c00091. Epub 2024 May 24.
3
Triboelectric Nanogenerator-Coated Blade Spray Mass Spectrometry for Volume-Limited Drug Analysis.用于体积受限药物分析的摩擦电纳米发电机涂层刀片喷雾质谱法。
Int J Mass Spectrom. 2024 Jan;495. doi: 10.1016/j.ijms.2023.117164. Epub 2023 Oct 20.
4
DiffN Selection of Tandem Mass Spectrometry Precursors.差异 N 法选择串联质谱前体。
Anal Chem. 2023 Jun 27;95(25):9581-9588. doi: 10.1021/acs.analchem.3c01085. Epub 2023 Jun 13.
5
Development of a dual-electrospray ionization source with in-line absorbance-based voltage control.基于在线吸光度的电压控制的双电喷雾电离源的开发。
Anal Bioanal Chem. 2023 Jul;415(18):4147-4152. doi: 10.1007/s00216-023-04564-3. Epub 2023 Jan 28.
6
Perturbation-induced high-frequency pulsing of nano-ESI with facile ion selection at atmospheric pressure.扰动诱导的纳米电喷雾离子化在大气压下的高频脉冲及简易离子选择
Analyst. 2020 Nov 9;145(22):7357-7371. doi: 10.1039/d0an01198c.
7
Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities.利用纳喷雾技术同时进行大气压化学电离和电泳分离，对复杂混合物进行直接质谱分析。
Anal Chem. 2019 Sep 17;91(18):11562-11568. doi: 10.1021/acs.analchem.9b01456. Epub 2019 Sep 6.
8
Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry.用于灵敏纳库仑分子质谱分析的摩擦电纳米发电机
Nat Nanotechnol. 2017 May;12(5):481-487. doi: 10.1038/nnano.2017.17. Epub 2017 Feb 27.
9
Increased Ion Transmission for Differential Ion Mobility Combined with Mass Spectrometry by Implementation of a Flared Inlet Capillary.通过采用扩口进样毛细管实现差分离子迁移率与质谱联用中的离子传输增加。
J Am Soc Mass Spectrom. 2017 Jan;28(1):119-124. doi: 10.1007/s13361-016-1509-7. Epub 2016 Oct 17.
10
Improved Differential Ion Mobility Separations Using Linked Scans of Carrier Gas Composition and Compensation Field.利用载气成分和补偿场的联动扫描改进差分离子迁移率分离
J Am Soc Mass Spectrom. 2015 Oct;26(10):1746-53. doi: 10.1007/s13361-015-1208-9. Epub 2015 Jul 7.
本文引用的文献
1
A new approach for the study of gas-phase ion-ion reactions using electrospray ionization.利用电喷雾电离研究气相离子-离子反应的新方法。
J Am Soc Mass Spectrom. 1992 Oct;3(7):695-705. doi: 10.1016/1044-0305(92)87082-A.
2
Micro-electrospray mass spectrometry: Ultra-high-sensitivity analysis of peptides and proteins.微电喷雾质谱法：肽和蛋白质的超高灵敏度分析。
J Am Soc Mass Spectrom. 1994 Jul;5(7):605-13. doi: 10.1016/1044-0305(94)85001-1.
3
Nano electrospray combined with a quadrupole ion trap for the analysis of peptides and protein digests.纳喷雾与四极离子阱联用分析肽和蛋白质酶解物。
J Am Soc Mass Spectrom. 1996 Feb;7(2):150-6. doi: 10.1016/1044-0305(95)00626-5.
4
A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap.一种用于电动离子阱中顺序离子/离子反应的脉冲三重电离源。
J Am Soc Mass Spectrom. 2007 Mar;18(3):369-76. doi: 10.1016/j.jasms.2006.10.004. Epub 2006 Nov 13.
5
Pulsation modes and the effect of applied voltage on current and flow rate in nanoelectrospray.纳米电喷雾中的脉动模式以及施加电压对电流和流速的影响。
Anal Chem. 2006 Apr 15;78(8):2658-64. doi: 10.1021/ac0520036.
6
Pulsed dual electrospray ionization for ion/ion reactions.用于离子/离子反应的脉冲双电喷雾电离
J Am Soc Mass Spectrom. 2005 Nov;16(11):1750-6. doi: 10.1016/j.jasms.2005.07.013. Epub 2005 Sep 22.
7
Utilization of capillary electrophoresis/mass spectrometry (CE/MSn) for the study of anthocyanin dyes.
J Sep Sci. 2005 Aug;28(12):1291-9. doi: 10.1002/jssc.200500071.
8
Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification.使用五通道多路复用电喷雾四极杆飞行时间混合质谱仪进行代谢物鉴定。
Rapid Commun Mass Spectrom. 2005;19(12):1611-8. doi: 10.1002/rcm.1964.
9
Comparison of liquid chromatography using triple quadrupole and quadrupole ion trap mass analyzers to determine pesticide residues in oranges.使用三重四极杆和四极杆离子阱质谱分析仪的液相色谱法测定橙子中农药残留的比较。
J Chromatogr A. 2005 Mar 4;1067(1-2):115-25. doi: 10.1016/j.chroma.2004.10.032.
10
Accurate mass measurement in nano-electrospray ionization mass spectrometry by alternate switching of high voltage between sample and reference sprayers.通过在样品喷雾器和参比喷雾器之间交替切换高压，在纳升电喷雾电离质谱中进行精确质量测量。
Rapid Commun Mass Spectrom. 2005;19(4):540-6. doi: 10.1002/rcm.1813.
Zotero 插件