与Apx和Shroom相关的蛋白质的新标准命名法。
A new standard nomenclature for proteins related to Apx and Shroom.
作者信息
Hagens Olivier, Ballabio Andrea, Kalscheuer Vera, Kraehenbuhl Jean-Pierre, Schiaffino M Vittoria, Smith Peter, Staub Olivier, Hildebrand Jeff, Wallingford John B
机构信息
Dept. of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
出版信息
BMC Cell Biol. 2006 Apr 14;7:18. doi: 10.1186/1471-2121-7-18.
Abstract
Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KIAA1202. In light of the growing interest in this family of proteins, we propose here a new standard nomenclature.
摘要
Shroom是一种最近被描述的在发育中的神经系统中调节细胞形状变化的因子。该蛋白是一个相关蛋白小家族的成员，这些蛋白通过序列相似性定义，并且在大多数情况下与肌动蛋白细胞骨架存在某种联系。目前，这些蛋白被命名为Shroom、APX、APXL和KIAA1202。鉴于对该蛋白家族的兴趣日益增加，我们在此提出一种新的标准命名法。
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本文引用的文献
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Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation.新型KIAA1202基因的破坏与X连锁智力迟钝有关。
Hum Genet. 2006 Jan;118(5):578-90. doi: 10.1007/s00439-005-0072-2. Epub 2005 Oct 26.
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Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network.Shroom蛋白通过肌动球蛋白网络的顶端定位来调节上皮细胞的形状。
J Cell Sci. 2005 Nov 15;118(Pt 22):5191-203. doi: 10.1242/jcs.02626. Epub 2005 Oct 25.
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Shroom induces apical constriction and is required for hingepoint formation during neural tube closure.Shroom蛋白诱导顶端收缩，是神经管闭合过程中铰链点形成所必需的。
Curr Biol. 2003 Dec 16;13(24):2125-37. doi: 10.1016/j.cub.2003.11.054.
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Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice.Shroom是一种含PDZ结构域的肌动蛋白结合蛋白，是小鼠神经管形态发生所必需的。
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Association of the epithelial sodium channel with Apx and alpha-spectrin in A6 renal epithelial cells.A6肾上皮细胞中上皮钠通道与Apx和α-血影蛋白的关联。
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Renal epithelial protein (Apx) is an actin cytoskeleton-regulated Na+ channel.
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Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region.从1型眼白化病关键区域克隆非洲爪蟾APX基因的人类同源基因。
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