无切割：胞质分裂受到控制。

NoCut: cytokinesis in check.

作者信息

Bloom Kerry

机构信息

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

Cell. 2006 Apr 7;125(1):17-8. doi: 10.1016/j.cell.2006.03.016.

DOI:10.1016/j.cell.2006.03.016

PMID:16615883

Abstract

In this issue of Cell, Norden et al. (2006) describe a new pathway, NoCut, that links the completion of chromosome segregation to the onset of cytokinesis in budding yeast. In NoCut, Aurora kinase (Ipl1) at the spindle midzone negatively regulates cytokinesis through two proteins previously identified to be involved in cell polarity, Boi1 and Boi2.

摘要

在本期《细胞》杂志中，诺登等人（2006年）描述了一条新的途径——NoCut，它将芽殖酵母中染色体分离的完成与胞质分裂的开始联系起来。在NoCut途径中，纺锤体中间区域的极光激酶（Ipl1）通过两种先前已确定参与细胞极性的蛋白质Boi1和Boi2对胞质分裂进行负调控。