Ward Kenneth
Department of Obstetrics and Gynecology and Women's Health and the Pacific Research Center for Early Human Development, University of Hawaii, John A. Burns School of Medicine, Honolulu, HI 96826, USA.
Am J Obstet Gynecol. 2006 Aug;195(2):364-72. doi: 10.1016/j.ajog.2005.12.014. Epub 2006 Apr 17.
Microarrays can be constructed with dozens to millions of probes on their surface to allow high-throughput analyses of many biologic processes to be performed simultaneously on the same sample. Microarrays are now widely used for gene expression analysis, deoxyribonucleic acid resequencing, single-nucleotide polymorphism genotyping, and comparative genomic hybridization. Microarray technology is accelerating research in many fields and now microarrays are moving into clinical application. This review discusses the emerging role of microarrays in molecular diagnostics, pathogen detection, oncology, and pharmacogenomics.
微阵列芯片表面可构建数十至数百万个探针,从而能够在同一样本上同时对多种生物过程进行高通量分析。微阵列芯片目前广泛应用于基因表达分析、脱氧核糖核酸重测序、单核苷酸多态性基因分型以及比较基因组杂交。微阵列技术正在加速许多领域的研究,如今微阵列芯片正迈向临床应用。本综述探讨了微阵列芯片在分子诊断、病原体检测、肿瘤学和药物基因组学中日益凸显的作用。