Klein G
Karolinska Institutet, Stockholm, Sweden.
Curr Opin Immunol. 1991 Oct;3(5):665-73. doi: 10.1016/0952-7915(91)90094-h.
The paradigmatic shift in cellular immunology, initiated by the realization that cytotoxic T lymphocytes recognize major histocompatibility complex class I antigens that carry endogenous (including virally encoded) protein-derived peptides in a special groove, has made a strong impact on the immunopathology of virus-associated tumors.
细胞免疫学的范式转变始于人们认识到细胞毒性T淋巴细胞识别主要组织相容性复合体I类抗原，这些抗原在一个特殊凹槽中携带内源性（包括病毒编码的）蛋白质衍生肽，这对病毒相关肿瘤的免疫病理学产生了重大影响。
