非霍奇金淋巴瘤病因学的某些方面。
Some aspects of the etiology of non-Hodgkin's lymphoma.
作者信息
Hardell L, Lindström G, van Bavel B, Fredrikson M, Liljegren G
机构信息
Department of Oncology, Orebro Medical Center, Sweden.
出版信息
Environ Health Perspect. 1998 Apr;106 Suppl 2(Suppl 2):679-81. doi: 10.1289/ehp.98106679.
Abstract
In epidemiologic studies, non-Hodgkin's lymphoma (NHL) has been associated with exposure to chemicals such as phenoxyacetic acids; chlorophenols; dioxins; organic solvents including benzene, polychlorinated biphenyls, chlordanes; and immunosuppressive drugs. Experimental evidence and clinical observations indicate that these chemicals may impair the immune system. The risk is increased for NHL in persons with acquired and congenital immune deficiency as well as autoimmune disorders. Also, certain viruses have been suggested to be of etiologic significance for NHL. In some cases of NHL the common mechanism for all these agents and conditions may be immunosuppression, possibly in combination with viruses.
摘要
在流行病学研究中，非霍奇金淋巴瘤（NHL）与接触某些化学物质有关，如苯氧乙酸、氯酚、二噁英；有机溶剂，包括苯、多氯联苯、氯丹；以及免疫抑制药物。实验证据和临床观察表明，这些化学物质可能损害免疫系统。获得性和先天性免疫缺陷患者以及自身免疫性疾病患者患NHL的风险会增加。此外，某些病毒也被认为与NHL的病因有关。在某些NHL病例中，所有这些因素和情况的共同机制可能是免疫抑制，可能还与病毒共同作用。
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