Villagrasa M, Boix J, Humbert P, Quer J C
Gastroenterology Unit, Germans Trias i Pujol Hospital Badalona, Barcelona, Spain.
Ital J Gastroenterol. 1991 Nov;23(8 Suppl 1):67-70.
We studied 114 patients affected by irritable bowel syndrome (IBS) (group A = 53 patients, group B = 61). Group A received diet with high content of roughage (20 g of fibers) and 10 g of bran, group B received otilonium bromide (OB) 40mg tid and normal diet (10-15 g of fibers). Abdominal pain, abdominal distension, bowel movements were evaluated before treatment (T0) at the end (T24) and after 12 months (T12). In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. In group A diet produced an improvement, albeit not significant, of the aforementioned parameters at T24. On the basis of our data OB seems to be more effective than a high-fiber diet in the treatment of IBS.
我们研究了114例肠易激综合征（IBS）患者（A组 = 53例患者，B组 = 61例）。A组接受高膳食纤维饮食（20克纤维）和10克麸皮，B组接受40毫克奥替溴铵每日三次及正常饮食（10 - 15克纤维）。在治疗前（T0）、结束时（T24）和12个月后（T12）评估腹痛、腹胀和排便情况。在B组中，与T0相比，奥替溴铵在T24时使腹痛和腹胀有显著改善（p小于0.01）。在A组中，饮食在T24时使上述参数有所改善，尽管不显著。根据我们的数据，奥替溴铵在治疗IBS方面似乎比高纤维饮食更有效。
