Defrance P, Casini A
Hepato-gastroenterology, University of Liège, Belgium.
Ital J Gastroenterol. 1991 Nov;23(8 Suppl 1):64-6.
We studied 40 patients with irritable bowel syndrome (IBS) which received in a simple-blind fashion otilonium and pinaverium bromide (15 days each drug). During each 15-day period we evaluated: number of pain episodes, intensity of pain, number of bowel movements, side effects. Otilonium bromide, (OB), compared with pinaverium bromide was able to significantly (p less than 0.05) reduce the number of pain attacks, whereas no significant differences were found between the 2 groups as regards the other parameters. The occurrence of side effects was similar in the two treatment courses. We can conclude that the two types of treatment were similarly useful in IBS, although OB seems more effective than pinaverium bromide.
我们研究了40例肠易激综合征（IBS）患者，这些患者以单盲方式接受奥替溴铵和匹维溴铵治疗（每种药物治疗15天）。在每个15天的治疗期间，我们评估了：疼痛发作次数、疼痛强度、排便次数、副作用。与匹维溴铵相比，奥替溴铵（OB）能够显著（p<0.05）减少疼痛发作次数，而在其他参数方面，两组之间未发现显著差异。两种治疗过程中副作用的发生情况相似。我们可以得出结论，两种治疗方法在IBS中同样有效，尽管OB似乎比匹维溴铵更有效。
