Simon Anne F, Liang Debbie T, Krantz David E
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Gonda Center for Neuroscience and Genetics, Room 3337C, 695 Charles Young Drive South, Los Angeles, CA 90095-1761, USA.
Mech Ageing Dev. 2006 Jul;127(7):647-51. doi: 10.1016/j.mad.2006.02.006. Epub 2006 Apr 17.
Normal aging is typically accompanied by deficits in behavioral performance, independent of overt pathology. In contrast, some behaviors remain relatively unchanged with age, but the reason(s) they remain intact are not known. Here we compare the relative impact of age on a battery of standard behavioral tests using the model genetic organism Drosophila melanogaster. Consistent with previous reports, learning, locomotion, geotaxis and phototaxis show a dramatic and progressive decline beginning at 1-2 weeks of age. In contrast, using two independent behavioral assays, we observe little or no decline in the flies' ability to escape potentially threatening stimuli. Using the assay with the most rapid decline, geotaxis, we observe a delay in functional aging in a long-lived mutant of the Ecdysone Receptor. We discuss the use of Drosophila genetics to investigate the differential decline in behavioral capacity.
正常衰老通常伴随着行为表现的缺陷，与明显的病理学无关。相比之下，一些行为随年龄增长相对保持不变，但其保持完好的原因尚不清楚。在这里，我们使用模式遗传生物黑腹果蝇比较年龄对一系列标准行为测试的相对影响。与之前的报告一致，学习、运动、负趋地性和趋光性从1 - 2周龄开始呈现显著且渐进的下降。相比之下，通过两项独立的行为分析，我们观察到果蝇逃避潜在威胁刺激的能力几乎没有下降。使用下降最快的负趋地性分析，我们在蜕皮激素受体的长寿突变体中观察到功能衰老的延迟。我们讨论了利用果蝇遗传学来研究行为能力的差异下降。
