Blanchet Fabien, Schurter Brandon T, Acuto Oreste
Molecular Immunology Unit, Institut Pasteur, Paris 75015, France.
Curr Opin Immunol. 2006 Jun;18(3):321-8. doi: 10.1016/j.coi.2006.03.001. Epub 2006 Apr 17.
Methylation of arginine is an additional option within the repertoire of post-translational modifications that proteins utilize for their communication with other partner proteins and nucleic acids, which ultimately contributes to cellular functions. Recent studies reveal that protein arginine methylation is more common and widespread than previously thought and that it is implicated in a number of key cellular processes including signal transduction. Two recent investigations have propelled this new world of protein modification into the immunological community by showing that TCR and CD28 signaling exploit this pathway. In contrast to other protein modifications utilized in intracellular signaling, arginine methylation seems to be long-lasting, raising interesting questions as to when, where and for what reason it can be utilized in the lymphocyte differentiation processes.
精氨酸甲基化是蛋白质用于与其他伴侣蛋白和核酸进行通讯的翻译后修饰方式中的一种额外选择，这最终有助于细胞功能的实现。最近的研究表明，蛋白质精氨酸甲基化比之前认为的更为常见和广泛，并且它参与了包括信号转导在内的许多关键细胞过程。最近的两项研究通过表明TCR和CD28信号传导利用了这一途径，将这个蛋白质修饰的新世界引入了免疫学界。与细胞内信号传导中使用的其他蛋白质修饰不同，精氨酸甲基化似乎是持久的，这就引发了关于它在淋巴细胞分化过程中何时、何地以及为何会被利用的有趣问题。
